Coxsackie Adenovirus Receptor antibody (C-Term)

Catalog No. ABIN3029697

This anti-Coxsackie Adenovirus Receptor antibody is a Rabbit Polyclonal antibody detecting Coxsackie Adenovirus Receptor in WB. Suitable for Human, Mouse and Rat.

Quick Overview for Coxsackie Adenovirus Receptor antibody (C-Term) (ABIN3029697)

Target: Coxsackie Adenovirus Receptor (CXADR) (Coxsackie Virus and Adenovirus Receptor (CXADR))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Coxsackie Adenovirus Receptor antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Coxsackie Adenovirus Receptor Antibody

Binding Specificity: C-Term

Purification: Antigen affinity

Immunogen: An amino acid sequence from the C-terminus of human Coxsackie Adenovirus Receptor (YSKTQYNQVPSEDFER) was used as the immunogen for this CAR antibody (100% homologous in human, mouse and rat).

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the CAR antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the CAR antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for Coxsackie Adenovirus Receptor

Target: Coxsackie Adenovirus Receptor (CXADR) (Coxsackie Virus and Adenovirus Receptor (CXADR))

Alternative Name: CAR Coxsackie Adenovirus Receptor

Background: Coxsackie virus and adenovirus receptor is a protein that in humans is encoded by the CXADR gene, also known as CAR, CVB3-binding protein, and Coxsackievirus B-adenovirus receptor. The cDNA encodes a predicted 365-amino acid polypeptide that contains a single transmembrane domain and is a member of the immunoglobulin superfamily. By Northern blot analysis, the highest expression of 1.4-kb and 6-kb transcripts are in pancreas, brain, heart, small intestine, testis, and prostate, lower expression in liver and lung, and no expression in kidney, placenta, peripheral blood leukocytes, thymus, and spleen. In comparison, mouse CAR showed highest expression in liver, and lower levels in kidney, heart, lung, and brain. The protein encoded by this gene is a type I membrane receptor for group B coxsackie viruses and subgroup C adenoviruses. Pseudogenes of this gene are found on chromosomes 15, 18, and 21. CAR is strongly expressed in the developing central nervous system. It functions as a homophilic and also as a heterophilic cell adhesion molecule through its interactions with extracellular matrix glycoproteins , such as: fibronectin, agrin, laminin-1 and tenascin-R.

UniProt: P78310

Pathways: Cell-Cell Junction Organization