Coxsackie Adenovirus Receptor antibody (AA 259-365)

Catalog No. ABIN7148649

Product Details anti-Coxsackie Adenovirus Receptor Antibody

Target: Coxsackie Adenovirus Receptor (CXADR) (Coxsackie Virus and Adenovirus Receptor (CXADR))

Binding Specificity: AA 259-365

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Coxsackie Adenovirus Receptor antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Coxsackievirus and adenovirus receptor protein (259-365AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Coxsackie Adenovirus Receptor

Target: Coxsackie Adenovirus Receptor (CXADR) (Coxsackie Virus and Adenovirus Receptor (CXADR))

Alternative Name: CXADR (CXADR Products)

Synonyms: CAR antibody, CAR4/6 antibody, HCAR antibody, Car1 antibody, car antibody, cb331 antibody, fb76g12 antibody, wu:fb76g12 antibody, 2610206D03Rik antibody, AU016810 antibody, AW553441 antibody, MCAR antibody, MCVADR antibody, hcar antibody, xCAR antibody, CXADR antibody, CXADR, Ig-like cell adhesion molecule antibody, coxsackie virus and adenovirus receptor antibody, CXADR, Ig-like cell adhesion molecule L homeolog antibody, CXADR antibody, Cxadr antibody, cxadr antibody, cxadr.L antibody

Background:

Background: Component of the epithelial apical junction complex that may function as an homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with AMICA1/JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, AMICA1 induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair.

Aliases: 46 kD coxsackievirus and adenovirus receptor CAR protein antibody, 46 kD coxsackievirus and adenovirus receptor protein antibody, CAR antibody, CAR4/6 antibody, Coxsackie virus and adenovirus receptor antibody, Coxsackie virus B receptor antibody, Coxsackievirus and adenovirus receptor antibody, Coxsackievirus B adenovirus receptor antibody, Coxsackievirus B-adenovirus receptor antibody, CVB3 binding protein antibody, CVB3-binding protein antibody, Cxadr antibody, CXADR Ig like cell adhesion molecule antibody, CXAR_HUMAN antibody, hCAR antibody, HCVADR antibody

UniProt: P78310

Pathways: Cell-Cell Junction Organization