Angiopoietin 2 antibody (AA 454-468)

Catalog No. ABIN3029949

This anti-Angiopoietin 2 antibody is a Rabbit Polyclonal antibody detecting Angiopoietin 2 in WB. Suitable for Human.

Quick Overview for Angiopoietin 2 antibody (AA 454-468) (ABIN3029949)

Target: Angiopoietin 2 (ANGPT2)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Angiopoietin 2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Angiopoietin 2 Antibody

Binding Specificity: AA 454-468

Purification: Antigen affinity

Immunogen: Amino acids 454-468 (NLNGMYYPQRQNTNK-human) were used as the immunogen for this Angiopoietin 2 antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the Angiopoietin 2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the Angiopoietin 2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for Angiopoietin 2

Target: Angiopoietin 2 (ANGPT2)

Alternative Name: Angiopoietin 2

Background: Angiopoietin 2 and -1 are involved in the development of the endothelium by regulating tyrosine phosphorylation of the membrane receptor Tie 2. Angiopoietin 2 is only 60 % homologous with -1. It is a naturally occurring antagonist of ANGPT1 that competes for binding to the TIE2 receptor and blocks ANGPT1-induced TIE2 autophosphorylation. ANGPT1 binding to Tie 2 causes phosphorylation of the receptor. Angiopoietin 2 competes for this binding, and thus blocks receptor phosphorylation. Angiopoietin 2 expression occurs at sites of vascular remodelling: dorsal aorta and major aortic branches, ovary, placenta and uterus.

UniProt: O15123

Pathways: RTK Signaling