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ITGAL antibody (AA 404-769)

ITGAL Reactivity: Human ICC, IF, IHC (p), WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3031369
$635.25
Plus shipping costs $45.00
100 μg
Shipping to: United States
Delivery in 2 to 3 Business Days
  • Target See all ITGAL Antibodies
    ITGAL (Integrin alpha-L (ITGAL))
    Binding Specificity
    • 15
    • 12
    • 9
    • 9
    • 8
    • 8
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 404-769
    Reactivity
    • 161
    • 78
    • 18
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 105
    • 79
    • 51
    • 7
    • 2
    Rabbit
    Clonality
    • 164
    • 78
    • 2
    Polyclonal
    Conjugate
    • 86
    • 30
    • 30
    • 22
    • 8
    • 7
    • 5
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ITGAL antibody is un-conjugated
    Application
    • 153
    • 67
    • 44
    • 43
    • 35
    • 27
    • 26
    • 26
    • 15
    • 14
    • 8
    • 8
    • 7
    • 7
    • 6
    • 2
    • 1
    • 1
    • 1
    Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
    Purification
    Antigen affinity
    Immunogen
    Human partial recombinant protein (AA 404-769) was used as the immunogen for this LFA-1 antibody.
    Isotype
    IgG
  • Application Notes
    The stated application concentrations are suggested starting amounts. Titration of the LFA-1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,IF/ICC: 1-2 μg/mL
    Restrictions
    For Research Use only
  • Buffer
    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
    Storage
    -20 °C
    Storage Comment
    After reconstitution, the LFA-1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • Target
    ITGAL (Integrin alpha-L (ITGAL))
    Alternative Name
    LFA-1 (ITGAL Products)
    Synonyms
    CD11A antibody, LFA-1 antibody, LFA1A antibody, (p180) antibody, Cd11a antibody, LFA-1A antibody, Ly-15 antibody, Ly-21 antibody, CD11a antibody, ITGAL antibody, integrin subunit alpha L antibody, integrin alpha L antibody, ITGAL antibody, Itgal antibody
    Background
    Lymphocyte function associated antigen 1, also known as CD18, is a protein that in humans is encoded by the ITGB2 gene. It is an integrin protein that belongs to the class of cell membrane glycoproteins. The beta-2 integrin chain gene is designated ITGB2 and the leukocyte antigen has been designated LFA-1/CD18. The expression of LFA-1 is increased in lymphoblastoid cells from persons with Down syndrome, consistent with the location of the gene on chromosome 21. In humans lack of LFA-1 causes Leukocyte Adhesion Deficiency, a disease defined by a lack of leukocyte extravasation from blood into tissues. Although the protein is expressed on the cell surface at normal levels and is capable of function following extracellular stimulation, it could not be activated via the 'inside-out' signaling pathways.
    Gene ID
    3689
    Pathways
    Activated T Cell Proliferation, Integrin Complex
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