BCL2A1 antibody (C-Term)

Catalog No. ABIN303175

This Rabbit Polyclonal antibody specifically detects BCL2A1 in WB and IHC (p). It exhibits reactivity toward Human and Mouse.

Quick Overview for BCL2A1 antibody (C-Term) (ABIN303175)

Target: BCL2A1 (BCL2-Related Protein A1 (BCL2A1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BCL2A1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-BCL2A1 Antibody

Binding Specificity: C-Term

Purification: Purified

Immunogen: Synthetic peptide corresponding to 14 amino acid peptide from near the carboxy terminus of human Bfl-1.

Application Details

Application Notes: Immunohistochemistry on Paraffin Sections (5 μg/mL). Western Blot.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate Buffered Saline PBS, containing 0.02 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer. Dilute only prior to immediate use.

Target Details for BCL2A1

Target: BCL2A1 (BCL2-Related Protein A1 (BCL2A1))

Background: This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and has been shown to be up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival.Synonyms: BCL2A1, BCL2L5, BFL1, Bcl-2-like protein 5, Bcl-2-related protein A1, GRS, HBPA1, Hemopoietic-specific early response protein, Protein BFL-1

Gene ID: 597

NCBI Accession: NP_004040

UniProt: Q16548