Neuregulin 2 antibody (Middle Region)

Catalog No. ABIN3031975

This Rabbit Polyclonal antibody specifically detects Neuregulin 2 in WB. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for Neuregulin 2 antibody (Middle Region) (ABIN3031975)

Target: Neuregulin 2 (NRG2)

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Neuregulin 2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Neuregulin 2 Antibody

Binding Specificity: Middle Region

Purification: Antigen affinity

Immunogen: An amino acid sequence from the middle region of human NRG2 (NGRKNSRLQFNKVKVEDA) was used as the immunogen for this NRG2 antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the NRG2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the NRG2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for Neuregulin 2

Target: Neuregulin 2 (NRG2)

Alternative Name: NRG2

Background: Neuregulin 2, also known as DON1 or NTAK, is a protein that in humans is encoded by the NRG2 gene. Neuregulin 2 is a member of the neuregulin family of growth and differentiation factors. Through interaction with the ErbB family of receptors, NRG2 induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The human gene contains 12 exons and the mouse Nrg2 gene contains 12 exons and spans about 180 kb. The genomic structure is similar to that of neuregulin 1(NRG1), another member of the neuregulin family of ligands. NRG1 and NRG2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. In particular, the neuregulin-ERBB signaling pathways play crucial roles in regulating the proliferation and differentiation of Schwann cells, the myelin-forming cells in the peripheral nervous system.

UniProt: O14511

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway