IL23A antibody (N-Term)

Catalog No. ABIN303269

The Rabbit Polyclonal anti-IL23A antibody is suitable to detect IL23A in samples from Human and Mouse. It has been validated for WB and IHC (p).

Quick Overview for IL23A antibody (N-Term) (ABIN303269)

Target: IL23A (Interleukin 23, alpha subunit p19 (IL23A))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL23A antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-IL23A Antibody

Binding Specificity: N-Term

Specificity: This antibody recognises Interleukin-23 Subunit alpha (SGRF).

Purification: Immunoaffinity Chromatography.

Immunogen: Synthetic Peptide corresponding to 16 amino acid peptide from near the amino terminus of human IL-23.

Application Details

Application Notes: Immunohistochemistry on Paraffin Sections (2.5 μg/mL). Western Blot (1-2 μg/mL).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate Buffered Saline PBS containing 0.02 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer. Dilute only prior to immediate use.

Target Details for IL23A

Target: IL23A (Interleukin 23, alpha subunit p19 (IL23A))

Alternative Name: Interleukin-23 alpha / IL23A

Background: IL23 is composed of the IL12 p40 subunit and a p19 subunit (IL23P19 or IL23A). The p19 subunit shares sequence similarity with IL6 subfamily members and is distantly related to the p35 subunit of IL12. It shows no biological activity by itself, instead, it combines with the p40 subunit of IL12 to form a biologically active, composite cytokine, IL23. IL12 and IL23 are molecules mainly produced by activated accessory and antigen-presenting cells. Both IL23 and IL12 can activate the transcription activator STAT4. In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. IL12 used to be thought to be the prime-regulator of TH1 development but upon discovery of IL23 and the fact that the large subunit of IL23 is shared by IL12, it is now thought that the features attributed to IL12 and TH1 development in inflammation are, in fact, dependent on IL23 rather than IL12. IL23 is implicated in protective and autoimmune responses.Synonyms: IL-23 subunit alpha, IL-23p19, Interleukin-23 subunit p19, SGRF

Gene ID: 51561

NCBI Accession: NP_057668

UniProt: Q9NPF7

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation