MUC5AC antibody (N-Term)

Catalog No. ABIN3042535

This Rabbit Polyclonal antibody specifically detects MUC5AC in IHC and WB. It exhibits reactivity toward Human. It has been mentioned in 3+ publications

Quick Overview for MUC5AC antibody (N-Term) (ABIN3042535)

Target: MUC5AC (Mucin 5AC, Oligomeric Mucus/gel-Forming (MUC5AC))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MUC5AC antibody is un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB)

Product Details anti-MUC5AC Antibody

Binding Specificity: N-Term

Purpose: Anti-Mucin 5AC/MUC5AC Antibody

Sequence: TMQLFMQLAP KLRGQT

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-Mucin 5AC/MUC5AC Antibody. Tested in IHC, WB applications. This antibody reacts with Human.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human Mucin 5AC.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Human Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains antibody formulated with stabilizing components, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Preservative: Thimerosal (Merthiolate), Sodium azide

Precaution of Use: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

References for anti-MUC5AC antibody (ABIN3042535)

Meziu, Shehu, Koch, Schneider, Kraegeloh: "Impact of mucus modulation by N-acetylcysteine on nanoparticle toxicity." in: International journal of pharmaceutics: X, Vol. 6, pp. 100212, (2023) (PubMed).

Jin, Kenny, Skoog, Padra, Adamczyk, Vitizeva, Thorell, Venkatakrishnan, Lindén, Karlsson: "Structural Diversity of Human Gastric Mucin Glycans." in: Molecular & cellular proteomics : MCP, Vol. 16, Issue 5, pp. 743-758, (2018) (PubMed).

Zhou, Perelman, Kolosov, Zhou: "Neutrophil elastase induces MUC5AC secretion via protease-activated receptor 2." in: Molecular and cellular biochemistry, Vol. 377, Issue 1-2, pp. 75-85, (2013) (PubMed).

Target Details for MUC5AC

Target: MUC5AC (Mucin 5AC, Oligomeric Mucus/gel-Forming (MUC5AC))

Alternative Name: MUC5AC

Background:

Background: Mucin-5AC is a protein that in humans is encoded by the MUC5AC gene. It is mapped to 11p15.5. MUC5AC is highly expressed in adult trachea and stomach. This gene has been linked to mucus hypersecretion in the pulmonary tracts and associated to chronic obstructive pulmonary disease (COPD). It has been showed that activation of the NF-kappa-B signaling pathway by inflammatory cytokine TNF-alpha upregulated MUC5AC mRNA expression nearly 6-fold. MUC5AC is also a and critical mediator of resistance during intestinal nematode infection.

Gene Full Name: mucin 5AC, oligomeric mucus/gel-forming

Sequence Similarities: Contains 1 CTCK (C-terminal cystine knot-like) domain.

Molecular Weight: 300 kDa

Gene ID: 4586

UniProt: P98088