LHCGR antibody (N-Term)

Catalog No. ABIN3042675

Cited in 1 publication. The Rabbit Polyclonal anti-LHCGR antibody (ABIN3042675) specifically detects LHCGR in WB and IHC. The antibody is reactive with Human and Rat samples.

Quick Overview for LHCGR antibody (N-Term) (ABIN3042675)

Target: LHCGR (Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LHCGR antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-LHCGR Antibody

Binding Specificity: N-Term

Purpose: Anti-hCG receptor/LHCGR Antibody

Sequence: YLSICNTGIR KFPDVTK

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Predicted Reactivity: different from the relative rat sequence by two amino acids,mouse sequence by three amino acids.

Characteristics: Anti-hCG receptor/LHCGR Antibody. Tested in IHC, WB applications. This antibody reacts with Human, Rat.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human hCG receptor, different from the relative rat sequence by two amino acids, mouse sequence by three amino acids.

Isotype: IgG

Application Details

Application Notes: Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Rat, Human Western blot, 0.1-0.5 μg/mL, Human, Rat

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains antibody formulated with stabilizing components, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Preservative: Thimerosal (Merthiolate), Sodium azide

Precaution of Use: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

References for anti-LHCGR antibody (ABIN3042675)

Wu, Shi, Gong, Yu, Chen, Wang, Sun: "Evaluation of follicular synchronization caused by estrogen administration and its reproductive outcome." in: PLoS ONE, Vol. 10, Issue 5, pp. e0127595, (2016) (PubMed).

Target Details for LHCGR

Target: LHCGR (Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR))

Alternative Name: LHCGR

Background:

Background: The luteinizing hormone/choriogonadotropin receptor is a member of a subfamily of G protein-coupled receptors (GPCR) characterized by the presence of a large N-terminal extracellular domain containing several leucine-rich repeats (LRR). This glycoprotein hormone receptor family has been named the LRR-containing GPCR (LGR) family. The LHCGR gene contains 11 exons and spans approximately 80 kb and it is mapped to chromosome 2p21. In the ovary, theca, stromal, late-stage (luteinizing) granulosa, and luteal cells contain LHCGR. In the testes, Leydig cells contain LHCRG.

Gene Full Name: luteinizing hormone/choriogonadotropin receptor

Sequence Similarities: Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.

Molecular Weight: 78 kDa

Gene ID: 3973

UniProt: P22888

Pathways: Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, cAMP Metabolic Process, Glycosaminoglycan Metabolic Process, Regulation of Carbohydrate Metabolic Process, Autophagy, Negative Regulation of intrinsic apoptotic Signaling