Interleukin 17a antibody (AA 26-158)

Catalog No. ABIN3042799

Product Details anti-Interleukin 17a Antibody

Target: Interleukin 17a (IL17A) (Interleukin 17A (IL17A))

Binding Specificity: AA 26-158

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Interleukin 17a antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Purpose: Rabbit IgG polyclonal antibody for Interleukin-17A(IL17A) detection. Tested with WB, ELISA in Mouse.

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for Interleukin-17A(IL17A) detection. Tested with WB, ELISA in Mouse.
Gene Name: interleukin 17A,Cytotoxic T-lymphocyte-associated antigen 8,CTLA-8
Protein Name: Interleukin-17A(IL-17/IL-17A)

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived mouse IL-17 recombinant protein(Position: A26-A158).

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Species: Mouse
ELISA: Concentration: 0.1-0.5 μg/mL, Species: Mouse

Notes: Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Expiry Date: 12 months

References for anti-Interleukin 17a antibody (ABIN3042799)

Li, Pan, Qiu: "Imbalances of Th17 and Treg cells and their respective cytokines in COPD patients by disease stage." in: International journal of clinical and experimental medicine, Vol. 7, Issue 12, pp. 5324-9, (2015) (PubMed).

Ma, Wang, Zhao, Pang, Zhang, Jiang, Liu, Mamuti, Wen, Ding: "Th17 cells are associated with the Th1/Th2?cell balance during Echinococcus multilocularis infection." in: Molecular medicine reports, Vol. 10, Issue 1, pp. 236-40, (2014) (PubMed).

Target Details for Interleukin 17a

Target: Interleukin 17a (IL17A) (Interleukin 17A (IL17A))

Alternative Name: IL17A (IL17A Products)

Synonyms: CTLA8 antibody, IL-17 antibody, IL-17A antibody, IL17 antibody, Ctla-8 antibody, Ctla8 antibody, Il17 antibody, ChIL-17 antibody, IL-17F antibody, IL17A antibody, CTLA-8 antibody, interleukin 17A antibody, IL17A antibody, Il17a antibody

Background: IL-17(Interleukin-17), originally identified as a transcript from a rodent T-cell hybridoma by Rouvier et al. in 1993, is the founding member of a group of cytokines called the IL-17 family. Known as CTLA8 in rodents, IL-17 shows high homology to viral IL-17 encoded by an open reading frame of the T-lymphotropic rhadinovirus Herpesvirus saimiri. Mouse IL-17 shares 85 % amino acid sequence homology with rat. Interleukin 17 is a cytokine that acts as a potent mediator in delayed-type reactions by increasing chemokine production in various tissues to recruit monocytes and neutrophils to the site of inflammation, similar to Interferon gamma. IL-17 is produced by T-helper cells and is induced by IL-23 which results in destructive tissue damage in delayed-type reactions. Interleukin 17 as a family functions as a proinflammatory cytokine that responds to the invasion of the immune system by extracellular pathogens and induces destruction of the pathogen's cellular matrix. Interleukin 17 acts synergistically with tumor necrosis factor and interleukin-1. To elicit its functions, IL-17 binds to a type I cell surface receptor called IL-17R of which there are at least three variants IL17RA, IL17RB, and IL17RC.

Synonyms: CTLA 8 antibody|CTLA-8 antibody|CTLA8 antibody|Cytotoxic T lymphocyte associated antigen 8 antibody|Cytotoxic T lymphocyte associated protein 8 antibody|Cytotoxic T lymphocyte associated serine esterase 8 antibody|Cytotoxic T-lymphocyte-associated antigen 8 antibody|IL 17A antibody|IL-17 antibody|IL-17A antibody|IL17 antibody|IL17A antibody|Interleukin 17 (cytotoxic T lymphocyte associated serine esterase 8) antibody|Interleukin 17A antibody|Interleukin-17A antibody|Interleukin17 antibodyInter|leukin17A antibody|OTTHUMP00000016597 antibody|OTTMUSP00000046003 antibody

UniProt: Q62386