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T-Bet antibody (C-Term)

Reactivity: Human, Rat WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3042957
  • Target See all T-Bet Antibodies
    T-Bet
    Binding Specificity
    • 9
    • 8
    • 6
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 522-535, C-Term
    Reactivity
    • 58
    • 27
    • 22
    • 7
    • 7
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    Human, Rat
    Host
    • 55
    • 6
    Rabbit
    Clonality
    • 54
    • 7
    Polyclonal
    Conjugate
    • 31
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This T-Bet antibody is un-conjugated
    Application
    • 53
    • 23
    • 11
    • 8
    • 7
    • 5
    • 5
    • 5
    • 3
    • 1
    • 1
    Western Blotting (WB)
    Purpose
    Rabbit IgG polyclonal antibody for T-box transcription factor TBX21(TBX21) detection. Tested with WB in Human,Mouse,Rat.
    Sequence
    DKEAEGQFYN YFPN
    Cross-Reactivity (Details)
    Predicted Cross Reactivity: mouse
    No cross reactivity with other proteins.
    Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.
    Characteristics
    Rabbit IgG polyclonal antibody for T-box transcription factor TBX21(TBX21) detection. Tested with WB in Human,Mouse,Rat.
    Gene Name: T-box 21
    Protein Name: T-box transcription factor TBX21
    Purification
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence at the C-terminus of human T-bet(522-535aa DKEAEGQFYNYFPN), different from the related rat and mouse sequences by one amino acid.
    Isotype
    IgG
    Top Product
    Discover our top product T-Bet Primary Antibody
  • Application Notes
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse, The detection limit for TBX21 is approximately 0.5 ng/lane under reducing conditions.
    Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
    Other applications have not been tested. Optimal dilutions should be determined by end users.
    Comment

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Preservative
    Thimerosal (Merthiolate), Sodium azide
    Precaution of Use
    This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
    Expiry Date
    12 months
  • Miao, Run-Ming, Yi: "T-Bet Mediated Anti-Neoplastic Effects of Dendritic Cell-Cytokine Induced Killer Cells in vitro." in: Iranian journal of pediatrics, Vol. 22, Issue 1, pp. 43-51, (2012) (PubMed).

  • Target
    T-Bet
    Alternative Name
    TBX21 (T-Bet Products)
    Synonyms
    T-PET antibody, T-bet antibody, TBET antibody, TBLYM antibody, TBT1 antibody, Tbet antibody, Tblym antibody, T-box 21 antibody, TBX21 antibody, Tbx21 antibody
    Background
    TBX21(T-Box 21), also called TBET, is a protein that in humans is encoded by the TBX21 gene. This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. Zhang and Yang(2000) mapped the mouse Tbx21 gene to chromosome 11D in an area showing homology of synteny with human chromosome 17. Szabo et al.(2000) showed that TBX21 expression correlates with IFNG expression in Th1 and natural killer(NK) cells. Ectopic expression of TBX21 both transactivated the IFNG gene and induced endogenous IFNG production. Finotto et al.(2002) observed reduced expression of the T(H)1 transcription factor Tbet in T cells from airways of patients with asthma compared with that in T cells from airways of nonasthmatic patients, suggesting that loss of Tbet might be associated with asthma.

    Synonyms: T bet antibody|T box 21 antibody|T box expressed in T cells antibody|T box protein 21 antibody|T box transcription factor TBX21 antibody|T cell specific T box transcription factor antibody|T cell specific T box transcription factor T bet antibody|T PET antibody|T-box protein 21 antibody|T-box transcription factor TBX21 antibody|T-cell-specific T-box transcription factor T-bet antibody|TBET antibody|TBLYM antibody|TBX 21 antibody|TBX21 antibody|TBX21_HUMAN antibody|TPET antibody|Transcription factor TBLYM antibody
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