LTK antibody (C-Term)

Catalog No. ABIN3042963

This anti-LTK antibody is a Rabbit Polyclonal antibody detecting LTK in WB. Suitable for Human.

Quick Overview for LTK antibody (C-Term) (ABIN3042963)

Target: LTK (Leukocyte Receptor tyrosine Kinase (LTK))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LTK antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-LTK Antibody

Binding Specificity: AA 850-864, C-Term

Purpose: Anti-LTK Antibody Picoband®

Sequence: RGLQPQNLWN PTYRS

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-LTK Antibody (ABIN3042963). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human LTK.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Human
1. Li, N., Nakamura, K., Jiang, Y., Tsurui, H., Matsuoka, S., Abe, M., Ohtsuji, M., Nishimura, H., Kato, K., Kawai, T., Atsumi, T., Koike, T., Shirai, T., Ueno, H., Hirose, S. Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus. Hum. Molec. Genet. 13: 171-179, 2004. 2. Liao, X., Zhou, R., Gilbert, D. J., Copeland, N. G., Jenkins, N. A. Receptor tyrosine kinase gene Tyro3 maps to mouse chromosome 2, closely linked to Ltk. Mammalian Genome 7: 395-396, 1996. 3. Toyoshima, H., Kozutsumi, H., Maru, Y., Hagiwara, K., Furuya, A., Mioh, H., Hanai, N., Takaku, F., Yazaki, Y., Hirai, H. Differently spliced cDNAs of human leukocyte tyrosine kinase receptor tyrosine kinase predict receptor proteins with and without a tyrosine kinase domain and a soluble receptor protein. Proc. Nat. Acad. Sci. 90: 5404-5408, 1993.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Preservative: Thimerosal (Merthiolate), Sodium azide

Precaution of Use: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for LTK

Target: LTK (Leukocyte Receptor tyrosine Kinase (LTK))

Alternative Name: LTK

Background:

Synonyms: Leukocyte tyrosine kinase receptor,2.7.10.1,Protein tyrosine kinase 1,LTK,TYK1,

Tissue Specificity: Expressed in non-hematopoietic cell lines and T- and B-cell lines. .

Background: LTK (Leukocyte Tyrosine Kinase), also known as TYK1, is an enzyme that in humans is encoded by the LTK gene. The protein encoded by this gene is a member of the ALK/LTK receptor family of receptor tyrosine kinases (RTKs) whose ligand is unknown. Toyoshima et al. (1993) cloned a set of cDNAs representing differently spliced human LTK mRNAs. Liao et al. (1996) found that the mouse Ltk gene is closely linked to the Tyro3 gene which maps to mouse chromosome 2. Thus, the LTK gene produces not only the putative receptor tyrosine kinase for an unknown ligand but also multiple protein products that may have different functions.

Sequence Similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

Molecular Weight: 85-91 kDa

UniProt: P29376

Pathways: RTK Signaling