IRF2 antibody (C-Term)

Catalog No. ABIN3043040

Product Details anti-IRF2 Antibody

Target: IRF2 (Interferon Regulatory Factor 2 (IRF2))

Binding Specificity: AA 249-266, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRF2 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Rabbit IgG polyclonal antibody for Interferon regulatory factor 2(IRF2) detection. Tested with WB in Human,Mouse,Rat.

Sequence: RPHWRKRNIE GKQYLSNM

Cross-Reactivity (Details): Predicted Cross Reactivity: mouse, rat
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Characteristics: Rabbit IgG polyclonal antibody for Interferon regulatory factor 2(IRF2) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: interferon regulatory factor 2
Protein Name: Interferon regulatory factor 2(IRF-2)

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human IRF2(249-266aa RPHWRKRNIEGKQYLSNM), identical to the related rat sequence and different from the related mouse sequence by one amino acid.

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Predicted Species: Mouse, Rat
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Preservative: Thimerosal (Merthiolate), Sodium azide

Precaution of Use: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for IRF2

Target: IRF2 (Interferon Regulatory Factor 2 (IRF2))

Alternative Name: IRF2 (IRF2 Products)

Synonyms: IRF-2 antibody, 9830146E22Rik antibody, AI646973 antibody, Irf-2 antibody, irf2b antibody, zgc:103451 antibody, irf-2 antibody, wu:fc74h04 antibody, zgc:76951 antibody, interferon regulatory factor 2 antibody, interferon regulatory factor 2 L homeolog antibody, interferon regulatory factor 2a antibody, IRF2 antibody, Irf2 antibody, irf2 antibody, irf2.L antibody, irf2a antibody

Background: IRF2(interferon regulatory factor 2) is a member of the interferon regulatory transcription factor(IRF) family. The IRF2 gene is mapped on 4q35.1. When the IRF2 gene was overexpressed in NIH 3T3 cells, the cells became transformed and displayed enhanced tumorigenicity in nude mice. One IRF binding site was found within the IRF2 promoter, and expression of the IRF2 gene was affected by both transient and stable IRF1 expression. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. Irf2 was required to prevent NK-cell apoptosis and keep immature NK cells alive, thus promoting NK-cell maturation and their supply to peripheral blood.

Synonyms: DKFZp686F0244 antibody|Interferon regulatory factor 2 antibody|IRF 2 antibody|IRF-2 antibody|IRF2 antibody|IRF2_HUMAN antibody

UniProt: P14316