Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

Oncostatin M antibody (Middle Region)

OSM Reactivity: Human WB, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN3043117
  • Target See all Oncostatin M (OSM) Antibodies
    Oncostatin M (OSM)
    Binding Specificity
    • 15
    • 7
    • 6
    • 6
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 181-198, Middle Region
    Reactivity
    • 56
    • 10
    • 9
    Human
    Host
    • 59
    • 7
    • 1
    • 1
    • 1
    Rabbit
    Clonality
    • 62
    • 7
    Polyclonal
    Conjugate
    • 36
    • 8
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Oncostatin M antibody is un-conjugated
    Application
    • 55
    • 31
    • 13
    • 13
    • 9
    • 6
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purpose
    Rabbit IgG polyclonal antibody for Oncostatin-M(OSM) detection. Tested with WB, IHC-P in Human.
    Sequence
    ASDAFQRKLE GCRFLHGY
    Cross-Reactivity (Details)
    No cross reactivity with other proteins.
    Characteristics
    Rabbit IgG polyclonal antibody for Oncostatin-M(OSM) detection. Tested with WB, IHC-P in Human.
    Gene Name: oncostatin M
    Protein Name: Oncostatin-M(OSM)
    Purification
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence in the middle region of human Oncostatin M(181-198aa ASDAFQRKLEGCRFLHGY).
    Isotype
    IgG
    Top Product
    Discover our top product OSM Primary Antibody
  • Application Notes
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
    IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
    Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.
    Comment

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Concentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Preservative
    Thimerosal (Merthiolate), Sodium azide
    Precaution of Use
    This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
    Expiry Date
    12 months
  • Zhu, Che, Liao, Wang, Wang, Chen, Wang, Dai, Wan: "Oncostatin M activates STAT3 to promote endometrial cancer invasion and angiogenesis." in: Oncology reports, Vol. 34, Issue 1, pp. 129-38, (2015) (PubMed).

  • Target
    Oncostatin M (OSM)
    Alternative Name
    OSM (OSM Products)
    Synonyms
    OSM antibody, OncoM antibody, oncostatin M antibody, OSM antibody, Osm antibody
    Background
    OSM(ONCOSTATIN M) is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. This gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. OSM is mapped on 22q12.2. OSM has the ability to inhibit the growth of human A375 melanoma cells but not normal human fibroblasts. Treatment with recombinant OSM leads to the inhibition of proliferation and changes in cellular morphology of a number of tumor cell lines derived from a wide variety of tissue types. OSM also has the ability to inhibit the proliferation of murine M1 myeloid leukemic cells and can induce their differentiation into macrophage-like cells, a function shared by LIF, CSF3, and IL6. The direction of gene transcription was telomeric to centromeric, with the OSM gene located upstream of the LIF gene.

    Synonyms: MGC20461 antibody|ONCM_HUMAN antibody|Oncostatin M antibody|Oncostatin M precursor antibody|Oncostatin-M antibody|OSM antibody
    UniProt
    P13725
    Pathways
    JAK-STAT Signaling, Negative Regulation of Hormone Secretion
You are here:
Support