Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

Monoamine Oxidase B antibody (N-Term)

This Rabbit Polyclonal antibody specifically detects Monoamine Oxidase B in WB and IHC. It exhibits reactivity toward Mouse and Rat.
Catalog No. ABIN3043132

Quick Overview for Monoamine Oxidase B antibody (N-Term) (ABIN3043132)

Target

See all Monoamine Oxidase B (MAOB) Antibodies
Monoamine Oxidase B (MAOB)

Reactivity

  • 62
  • 34
  • 14
  • 5
  • 4
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 1
Mouse, Rat

Host

  • 62
  • 3
  • 1
  • 1
Rabbit

Clonality

  • 55
  • 12
Polyclonal

Conjugate

  • 35
  • 4
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This Monoamine Oxidase B antibody is un-conjugated

Application

  • 51
  • 21
  • 19
  • 13
  • 13
  • 12
  • 7
  • 5
  • 3
  • 3
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC)
  • Binding Specificity

    • 15
    • 7
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 42-56, N-Term

    Purpose

    Anti-Monoamine Oxidase B/MAOB Antibody Picoband®

    Sequence

    RTYTIRNKNV KYVDL

    Cross-Reactivity (Details)

    No cross-reactivity with other proteins

    Characteristics

    Anti-Monoamine Oxidase B/MAOB Antibody (ABIN3043132). Tested in IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Purification

    Immunogen affinity purified.

    Immunogen

    A synthetic peptide corresponding to a sequence at the N-terminus of mouse MAOB, identical to the related rat sequence.

    Isotype

    IgG
  • Application Notes

    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Mouse, Rat
    Western blot, 0.1-0.5 μg/mL, Mouse, Rat
    1. Bach, A. W., Lan, N. C., Johnson, D. L., Abell, C. W., Bembenek, M. E., Kwan, S.-W., Seeburg, P. H., Shih, J. C. cDNA cloning of human liver monoamine oxidase A and B: molecular basis of differences in enzymatic properties. Proc. Nat. Acad. Sci. 85: 4934-4938, 1988. 2. Binda, C., Newton-Vinson, P., Hubalek, F., Edmondson, D. E., Mattevi, A. Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders. Nature Struct. Biol. 9: 22-26, 2002. 3. Edmondson DE, Binda C, Mattevi A (2007). "STRUCTURAL INSIGHTS INTO THE MECHANISM OF AMINE OXIDATION BY MONOAMINE OXIDASES A AND B". Archives of Biochemistry and Biophysics 464 (2): 269-76.

    Comment

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Restrictions

    For Research Use only
  • Format

    Lyophilized

    Reconstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Concentration

    500 μg/mL

    Buffer

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

    Preservative

    Thimerosal (Merthiolate), Sodium azide

    Precaution of Use

    This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

    Handling Advice

    Avoid repeated freezing and thawing.

    Storage

    4 °C,-20 °C

    Storage Comment

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

    Expiry Date

    12 months
  • Target

    Monoamine Oxidase B (MAOB)

    Alternative Name

    MAOB

    Background

    Synonyms: Amine oxidase [flavin-containing] B,1.4.3.4,Monoamine oxidase type B,MAO-B,Maob,

    Tissue Specificity: Heart, liver, duodenum, blood vessels and kidney.

    Background: MAOB (MONOAMINE OXIDASE B), also called MAO, BRAIN, AMINE OXIDASE (FLAVIN-CONTAINING) B, is a protein that in humans is encoded by the MAOB gene. MAOB is a member of the flavin monoamine oxidase family. And it is mapped on Xp11.3. MAOB catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine. Like MAOA, it also degrades dopamine. MAO-B is involved in the breakdown of dopamine, a neurotransmitter implicated in reinforcing and motivating behaviors as well as movement. MAO-B inhibition is, therefore, associated with enhanced activity of dopamine, as well as with decreased production of hydrogen peroxide, a source of reactive oxygen species.

    Sequence Similarities: Belongs to the flavin monoamine oxidase family.

    Molecular Weight

    59 kDa
You are here:
Chat with us!