CD147 antibody (Middle Region)

Catalog No. ABIN3043170

Product Details anti-CD147 Antibody

Target: CD147 (BSG) (Basigin (Ok Blood Group) (BSG))

Binding Specificity: AA 186-203, Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD147 antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Rabbit IgG polyclonal antibody for Basigin(BSG) detection. Tested with WB in Human.

Sequence: QKTEFKVDSD DQWGEYSC

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for Basigin(BSG) detection. Tested with WB in Human.
Gene Name: basigin(Ok blood group)
Protein Name: Basigin

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human CD147(186-203aa QKTEFKVDSDDQWGEYSC).

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Preservative: Thimerosal (Merthiolate), Sodium azide

Precaution of Use: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Expiry Date: 12 months

References for anti-CD147 antibody (ABIN3043170)

Zhang, Yang, Liu, Liu, Teng, Zhang, Yin, Liu et al.: "iTRAQ-coupled 2D LC/MS-MS analysis of CXCR7-transfected papillary thyroid carcinoma cells: A new insight into CXCR7 regulation of papillary thyroid carcinoma progression and identification of ..." in: Oncology letters, Vol. 14, Issue 3, pp. 3734-3740, (2017) (PubMed).

Xiao, Zhao, Shen, Liang, Chen: "Overexpression of CD147 is associated with poor prognosis, tumor cell migration and ERK signaling pathway activation in hepatocellular carcinoma." in: Experimental and therapeutic medicine, Vol. 14, Issue 3, pp. 2637-2642, (2017) (PubMed).

Lu, Lv, Kim, Ha, Kim: "Expression and clinical significance of extracellular matrix metalloproteinase inducer, EMMPRIN/CD147, in human osteosarcoma." in: Oncology letters, Vol. 5, Issue 1, pp. 201-207, (2012) (PubMed).

Target Details for CD147

Target: CD147 (BSG) (Basigin (Ok Blood Group) (BSG))

Alternative Name: BSG (BSG Products)

Synonyms: EMMPRIN antibody, RPE7 antibody, 5F7 antibody, CD147 antibody, M6 antibody, OK antibody, TCSF antibody, AI115436 antibody, AI325119 antibody, HT-7 antibody, 5A11 antibody, CE9 antibody, HT7 antibody, Ox47R antibody, basignin antibody, wu:fb26a05 antibody, wu:fo98e12 antibody, bsg antibody, prso03 antibody, basigin (Ok blood group) antibody, basigin antibody, basigin (Ok blood group) S homeolog antibody, BSG antibody, Bsg antibody, bsg antibody, bsg.S antibody

Background: Emmprin, extracellular matrix metalloproteinase inducer, also known as Emmprin(BSG) or cluster of differentiation 147(CD147) is a protein that in humans is encoded by the Emmprin gene. the BSG gene contains 8 exons and spans 10.8 kb. The human BSG gene is mapped to 19p13.3. This protein is a determinant for the Ok blood group system. Emmprin has been shown to be an essential receptor on red blood cells for the malaria parasite. Emmprin is a member of the immunoglobulin superfamily, with a structure related to the putative primordial form of the family. As members of the immunoglobulin superfamily play fundamental roles in intercellular recognition involved in various immunologic phenomena, differentiation, and development, Emmprin is though also to play a role in intercellular recognition. Emmprin also regulates several distinct functions, such as spermatogenesis, expression of the monocarboxylate transporter and the responsiveness of lymphocytes. Emmprin is a type I integral membrane receptor that has many ligands, including the cyclophilin(CyP) proteins Cyp-A and CyP-B and certain integrins. It is expressed by many cell types, including epithelial cells, endothelial cells and leukocytes.

Synonyms: 5A11 antigen antibody|5F7 antibody|BASI_HUMAN antibody|Basigin(Ok blood group) antibody|Basigin antibody|Blood brain barrier HT7 antigen antibody|Blood-brain barrier HT7 antigen antibody|BSG antibody|CD 147 antibody|CD147 antibody|CD147 antigen antibody|Collagenase stimulatory factor antibody|Emmprin antibody|Extracellular matrix metalloproteinase inducer antibody|Leukocyte activation antigen M6 antibody|M 6 antibody|M6 antibody|M6 leukocyte activation antigen antibody|neurothelin antibody|OK antibody|OK blood group antibody|OK blood group antigen antibody|TCSF antibody|Tumor cell derived collagenase stimulatory factor antibody|Tumor cell-derived collagenase stimulatory factor antibody

UniProt: P35613

Pathways: S100 Proteins