IL12B antibody (N-Term)

Catalog No. ABIN3043199

Product Details anti-IL12B Antibody

Target: IL12B (Interleukin 12 beta (IL12B))

Binding Specificity: AA 23-40, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL12B antibody is un-conjugated

Application: Western Blotting (WB)

Purpose: Rabbit IgG polyclonal antibody for Interleukin-12 subunit beta(IL12B) detection. Tested with WB in Human.

Sequence: IWELKKDVYV VELDWYPD

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for Interleukin-12 subunit beta(IL12B) detection. Tested with WB in Human.
Gene Name: interleukin 12B(natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
Protein Name: Interleukin-12 subunit beta(IL-12B)

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human IL-12(p40)(23-40aa IWELKKDVYVVELDWYPD).

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Preservative: Thimerosal (Merthiolate), Sodium azide

Precaution of Use: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Expiry Date: 12 months

References for anti-IL12B antibody (ABIN3043199)

Dong, Xia, Chen, Chen, Zhang: "Anti-arthritis activity of cationic materials." in: Journal of cellular and molecular medicine, Vol. 14, Issue 7, pp. 2015-24, (2011) (PubMed).

Target Details for IL12B

Target: IL12B (Interleukin 12 beta (IL12B))

Alternative Name: IL12B (IL12B Products)

Synonyms: CLMF antibody, CLMF2 antibody, IL-12B antibody, NKSF antibody, NKSF2 antibody, p40 antibody, Il-12b antibody, Il12p40 antibody, Il-12p40 antibody, Il12 antibody, IL-12p40 antibody, IL-12 antibody, IL-12 p40 antibody, il12b antibody, il12p40.b antibody, zgc:152789 antibody, IL-12.p40 antibody, IL12p40 antibody, IL12B antibody, CLMF p40 antibody, interleukin 12B antibody, interleukin 12b antibody, interleukin 12Ba antibody, IL12B antibody, Il12b antibody, il12ba antibody

Background: IL-12, Interleukin 12, heterodimerizes with the IL12 p35 subunit to form IL12 and with the IL23 p19 subunit to form IL23. IL12b p 40 exists as a monomer and as a homodimer. This gene encodes a subunit of Interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The IL-12b gene contains 8 exons, the first and last of which are noncoding. By PCR analysis of DNA from rodent/human cell hybrids containing intact chromosomes or translocation chromosomes, the IL-12b gene is mapped to 5q31-q33.This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen.

Synonyms: 40 kD Subunit antibody|CLMF 2 antibody|CLMF antibody|CLMF p40 antibody|CLMF2 antibody|Cytotoxic lymphocyte maturation factor 2 antibody|Cytotoxic lymphocyte maturation factor 2 p40 antibody|Cytotoxic lymphocyte maturation factor 40 kDa subunit antibody|HGNC:5970 antibody|IL 12 subunit p40 antibody|IL 12B antibody|IL-12 subunit p40 antibody|IL-12B antibody|IL12 subunit p40 antibody|IL12B antibody|IL12B_HUMAN antibody|Interleukin 12 beta chain antibody|Interleukin 12 p40 antibody|Interleukin 12 subunit beta antibody|Interleukin 12B antibody|Interleukin-12 subunit beta antibody|Natural killer cell stimulatory factor 2 antibody|NK cell stimulatory factor chain 2 antibody|NKSF 2 antibody|NKSF antibody|NKSF2 antibody|p40 antibody|TcMF antibody|TSF antibody

UniProt: P29460

Pathways: JAK-STAT Signaling, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation