FGF22 antibody (Middle Region)

Catalog No. ABIN3043207

This Rabbit Polyclonal antibody specifically detects FGF22 in WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for FGF22 antibody (Middle Region) (ABIN3043207)

Target: FGF22 (Fibroblast Growth Factor 22 (FGF22))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FGF22 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FGF22 Antibody

Binding Specificity: AA 93-109, Middle Region

Purpose: Anti-Fibroblast growth factor 22 FGF22 Antibody Picoband®

Sequence: FYVAMNRRGR LYGSRLY

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-Fibroblast growth factor 22 FGF22 Antibody (ABIN3043207). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human FGF22, different from the related mouse and rat sequences by one amino acid.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Human, Rat, Mouse
1. Nakatake, Y., Hoshikawa, M., Asaki, T., Kassai, Y., Itoh, N.Identification of a novel fibroblast growth factor, FGF-22, preferentially expressed in the inner root sheath of the hair follicle.Biochim. Biophys. Acta 1517: 460-463, 2001. 2. Terauchi, A., Johnson-Venkatesh, E. M., Toth, A. B., Javed, D., Sutton, M. A., Umemori, H.Distinct FGFs promote differentiation of excitatory and inhibitory synapses.Nature 465: 783-787, 2010. 3. Umemori, H., Linhoff, M. W., Ornitz, D. M., Sanes, J. R. FGF22 and its close relatives are presynaptic organizing molecules in the mammalian brain.Cell 118: 257-270, 2004.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Preservative: Thimerosal (Merthiolate), Sodium azide

Precaution of Use: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for FGF22

Target: FGF22 (Fibroblast Growth Factor 22 (FGF22))

Alternative Name: FGF22

Background:

Synonyms: Fibroblast growth factor 22,FGF-22,FGF22,UNQ2500/PRO5800,

Background: FGF22, Fibroblast growth factor 22, is a protein which in humans is encoded by the FGF22 gene. The FGF22 sequence in a genomic clone is assigned to 19p13.3. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. In situ hybridization demonstrated expression in the inner root sheath of the hair follicle. FGF22 is involved in hair development.

Sequence Similarities: Belongs to the heparin-binding growth factors family.

Molecular Weight: 24 kDa

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway