BAG2 antibody (AA 1-211)

Catalog No. ABIN3043508

Product Details anti-BAG2 Antibody

Target: BAG2 (BCL2-Associated Athanogene 2 (BAG2))

Binding Specificity: AA 1-211

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BAG2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Rabbit IgG polyclonal antibody for BAG family molecular chaperone regulator 2(BAG2) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Cross-Reactivity (Details): No cross reactivity with other proteins.

Characteristics: Rabbit IgG polyclonal antibody for BAG family molecular chaperone regulator 2(BAG2) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: BCL2-associated athanogene 2
Protein Name: BAG family molecular chaperone regulator 2

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human BAG2 recombinant protein (Position: M1-N211). Human BAG2 shares 93.4% amino acid (aa) sequence identity with mouse BAG2.

Isotype: IgG

Application Details

Application Notes: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Target Details for BAG2

Target: BAG2 (BCL2-Associated Athanogene 2 (BAG2))

Alternative Name: BAG2 (BAG2 Products)

Synonyms: bag2 antibody, MGC89300 antibody, BAG2 antibody, ATBAG2 antibody, BCL-2-associated athanogene 2 antibody, MTG10.13 antibody, MTG10_13 antibody, BAG-2 antibody, dJ417I1.2 antibody, zgc:64195 antibody, 2610042A13Rik antibody, BC016230 antibody, BCL2 associated athanogene 2 antibody, BCL-2-associated athanogene 2 antibody, BCL2-associated athanogene 2 antibody, Bcl2-associated athanogene 2 antibody, bag2 antibody, BAG2 antibody, Bag2 antibody

Background: BAG family molecular chaperone regulator 2 is a protein that in humans is encoded by the BAG2 gene. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. The functional antagonisms displayed between BAG family proteins and Hip suggest that a proper balance of these 2 types of protein is required for achieving optimal cycles of substrate binding and release required for inducting conformational changes in proteins, with Hip promoting peptide substrate binding by Hsc70/Hsp70 and BAG family proteins promoting dissociation.

Synonyms: BAG 2 antibody|BAG family molecular chaperone regulator 2 antibody|BAG-2 antibody|BAG-family molecular chaperone regulator-2 antibody|Bag2 antibody|BAG2_HUMAN antibody|BCL 2 associated athanogene 2 antibody|Bcl-2-associated athanogene 2 antibody|BCL2 associated athanogene 2 antibody|BCL2-associated athanogene 2 antibody|dJ417I1.2 (BAG family molecular chaperone regulator 2) antibody|dJ417I1.2 antibody|KIAA0576 antibody|MGC149462 antibody| OTTHUMP00000016668 antibody

Gene ID: 9532

UniProt: O95816