TREX1 antibody (Middle Region)

Catalog No. ABIN3043537

This Rabbit Polyclonal antibody specifically detects TREX1 in WB. It exhibits reactivity toward Human.

Quick Overview for TREX1 antibody (Middle Region) (ABIN3043537)

Target: TREX1 (three Prime Repair Exonuclease 1 (TREX1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TREX1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TREX1 Antibody

Binding Specificity: AA 156-185, Middle Region

Purpose: Anti-TREX1 Antibody Picoband®

Sequence: DDNLANLLLA FLRRQPQPWC LVAHNGDRYD

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-TREX1 Antibody Picoband® (ABIN3043537). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human TREX1, different from the related mouse sequence by four amino acids.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Human
1. "Entrez Gene: TREX1 three prime repair exonuclease 1". 2. Mazur DJ, Perrino FW (Aug 1999). "Identification and expression of the TREX1 and TREX2 cDNA sequences encoding mammalian 3'-->5' exonucleases". J Biol Chem 274 (28): 19655-60.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for TREX1

Target: TREX1 (three Prime Repair Exonuclease 1 (TREX1))

Alternative Name: TREX1

Background:

Synonyms: Three-prime repair exonuclease 1,3.1.11.2,3'-5' exonuclease TREX1,DNase III,TREX1,

Tissue Specificity: Detected in thymus, spleen, liver, brain, heart, small intestine and colon. .

Background: Three prime repair exonuclease 1 is an enzyme that in humans is encoded by the TREX1 gene. This gene encodes a nuclear protein with 3' exonuclease activity. The encoded protein may play a role in DNA repair and serve as a proofreading function for DNA polymerase. It is also a component of the SET complex, and acts to rapidly degrade 3' ends of nicked DNA during granzyme A-mediated cell death. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, Cree encephalitis, and other diseases of the immune system. Alternative splicing results in multiple transcript variants.

Molecular Weight: 33 kDa

Gene ID: 11277

Pathways: Apoptosis