TREX1 antibody (AA 1-270)

Catalog No. ABIN7172071

Product Details anti-TREX1 Antibody

Target: TREX1 (three Prime Repair Exonuclease 1 (TREX1))

Binding Specificity: AA 1-270

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TREX1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Three-prime repair exonuclease 1 protein (1-270AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IP:1:200-1:2000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for TREX1

Target: TREX1 (three Prime Repair Exonuclease 1 (TREX1))

Alternative Name: TREX1 (TREX1 Products)

Synonyms: AGS1 antibody, CRV antibody, DRN3 antibody, HERNS antibody, 1661 antibody, AU041952 antibody, RGD1309596 antibody, three prime repair exonuclease 1 antibody, CpipJ_CPIJ012074 antibody, Tsp_03749 antibody, TREX1 antibody, Trex1 antibody

Background:

Background: Major cellular 3\\\'-to-5\\\' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3\\\' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. Unless degraded, these DNA fragments accumulate in the cytosol and activate the IFN-stimulatory DNA (ISD) response and innate immune signaling. Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the processing of aberrant DNA replication intermediates. Inefficiently degrades oxidized DNA, such as that generated upon antimicrobial reactive oxygen production or upon absorption of UV light. During GZMA-mediated cell death, contributes to DNA damage in concert with NME1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3\\\' end to enhance DNA damage and prevent DNA end reannealing and rapid repair.

Aliases: TREX1 antibody, Three-prime repair exonuclease 1 antibody, EC 3.1.11.2 antibody, 3'-5' exonuclease TREX1 antibody, Deoxyribonuclease III antibody, DNase III antibody

UniProt: Q9NSU2

Pathways: Apoptosis