Neuregulin 1 antibody (AA 2-241)

Catalog No. ABIN3043580

The Rabbit Polyclonal anti-Neuregulin 1 antibody has been validated for WB. It is suitable to detect Neuregulin 1 in samples from Human. There is 1 publication available.

Quick Overview for Neuregulin 1 antibody (AA 2-241) (ABIN3043580)

Target: Neuregulin 1 (NRG1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Neuregulin 1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-Neuregulin 1 Antibody

Binding Specificity: AA 2-241

Purpose: Anti-NRG1 Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-NRG1 Antibody Picoband® (ABIN3043580). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human NRG1 recombinant protein (Position: S2-K241). Human NRG1 shares 94% amino acid (aa) sequence identity with rat NRG1.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Human
1. Fazzari, P., Paternain, A. V., Valiente, M., Pla, R., Lujan, R., Lloyd, K., Lerma, J., Marin, O., Rico, B.Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling. Nature 464: 1376-1380, 2010. 2. Go, R. C. P., Perry, R. T., Wiener, H., Bassett, S. S., Blacker, D., Devlin, B., Sweet, R. A. Neuregulin-1 polymorphism in late onset Alzheimer's disease families with psychoses. Am. J. Med. Genet. 139B: 28-32, 2005.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

References for anti-Neuregulin 1 antibody (ABIN3043580)

Wang, Zhou, Ding, Zhu, Jiang, Fu, Wang, Hu, Ge: "Qiliqiangxin improves cardiac function and attenuates cardiac remodeling in rats with experimental myocardial infarction." in: International journal of clinical and experimental pathology, Vol. 8, Issue 6, pp. 6596-606, (2015) (PubMed).

Target Details for Neuregulin 1

Target: Neuregulin 1 (NRG1)

Alternative Name: NRG1

Background:

Synonyms: Pro-neuregulin-1, membrane-bound isoform,Pro-NRG1,Neuregulin-1,Acetylcholine receptor-inducing activity,ARIA,Breast cancer cell differentiation factor p45,Glial growth factor,Heregulin,HRG,Neu differentiation factor,Sensory and motor neuron-derived factor,NRG1,GGF, HGL, HRGA, NDF, SMDF,

Tissue Specificity: Type I isoforms are the predominant forms expressed in the endocardium. Isoform alpha is expressed in breast, ovary, testis, prostate, heart, skeletal muscle, lung, placenta liver, kidney, salivary gland, small intestine and brain, but not in uterus, stomach, pancreas, and spleen. Isoform 3 is the predominant form in mesenchymal cells and in non-neuronal organs, whereas isoform 6 is the major neuronal form. Isoform 8 is expressed in spinal cord and brain. Isoform 9 is the major form in skeletal muscle cells, in the nervous system it is expressed in spinal cord and brain. Also detected in adult heart, placenta, lung, liver, kidney, and pancreas. Isoform 10 is expressed in nervous system: spinal cord motor neurons, dorsal root ganglion neurons, and brain. Predominant isoform expressed in sensory and motor neurons. Not detected in adult heart, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Not expressed in fetal lung, liver and kidney. Type IV isoforms are brain-specific. .

Background: The protein encoded by this gene is a membrane glycoprotein that that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD).

Sequence Similarities: Belongs to the neuregulin family.

Molecular Weight: 70 kDa

Gene ID: 3084

UniProt: Q02297

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation