P2RX5 antibody (AA 333-422)

Catalog No. ABIN3043894

This Rabbit Polyclonal antibody specifically detects P2RX5 in WB and IHC. It exhibits reactivity toward Human, Rat and Mouse.It has been mentioned in 1 publication

Quick Overview for P2RX5 antibody (AA 333-422) (ABIN3043894)

Target: P2RX5 (Purinergic Receptor P2X, Ligand-Gated Ion Channel, 5 (P2RX5))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This P2RX5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-P2RX5 Antibody

Binding Specificity: AA 333-422

Purpose: Anti-P2X5/P2RX5 Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-P2X5/P2RX5 Antibody (ABIN3043894). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human P2X5 recombinant protein (Position: D333-T422). Human P2X5 shares 42% amino acid (aa) sequence identity with rat P2X5.

Isotype: IgG

Application Details

Application Notes: Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Mouse, Rat, Human
Western blot, 0.1-0.5 μg/mL, Rat, Human

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

References for anti-P2RX5 antibody (ABIN3043894)

Meng, Zheng, Yan, Li, Fang, Li: "P2X2 and P2X5 Receptors Mediate Bladder Hyperesthesia in ICC in Female Overactive Bladder." in: Cell biochemistry and biophysics, Vol. 72, Issue 2, pp. 375-83, (2016) (PubMed).

Target Details for P2RX5

Target: P2RX5 (Purinergic Receptor P2X, Ligand-Gated Ion Channel, 5 (P2RX5))

Alternative Name: P2RX5

Background:

Synonyms: P2X purinoceptor 5,P2X5,ATP receptor,Purinergic receptor,P2RX5,P2X5,

Tissue Specificity: Expressed at high levels in brain and immune system.

Background: P2X purinoceptor 5 is a protein that in humans is encoded by the P2RX5 gene. The product of this gene belongs to the family of purinoceptors for ATP. It has been identified that the P2RX5 gene within a BAC contig covering chromosome 17p13. This receptor functions as a ligand-gated ion channel. Several characteristic motifs of ATP-gated channels are present in its primary structure, but, unlike other members of the purinoceptors family, this receptor has only a single transmembrane domain. Quantitative dot blots revealed that P2X5R expression is highest in brain and immune system and is developmentally regulated.

Sequence Similarities: Belongs to the P2X receptor family.

Molecular Weight: 47 kDa

Gene ID: 5026

UniProt: Q93086