ADAM19 antibody (N-Term)

Catalog No. ABIN3044069

The Rabbit Polyclonal anti-ADAM19 antibody has been validated for WB. It is suitable to detect ADAM19 in samples from Human.

Quick Overview for ADAM19 antibody (N-Term) (ABIN3044069)

Target: ADAM19 (Adam19) (ADAM Metallopeptidase Domain 19 (Adam19))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ADAM19 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ADAM19 Antibody

Binding Specificity: AA 286-298, N-Term

Purpose: Anti-ADAM19 Antibody Picoband®

Sequence: RRKLLAQKYH DNA

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-ADAM19 Antibody (ABIN3044069). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human ADAM19, different from the related mouse sequence by one amino acid, and from the related rat sequence by two amino acids.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Human
1. Hirohata, S., Seldin, M. F., Apte, S. S. Chromosomal assignment of two ADAM genes, TACE (ADAM17) and MLTNB (ADAM19), to human chromosomes 2 and 5, respectively, and of Mltnb to mouse chromosome 11. Genomics 54: 178-179, 1998. 2. Inoue, D., Reid, M., Lum, L., Kratzschmar, J., Weskamp, G., Myung, Y. M., Baron, R., Blobel, C. P. Cloning and initial characterization of mouse meltrin beta and analysis of the expression of four metalloprotease-disintegrins in bone cells. J. Biol. Chem. 273: 4180-4187, 1998.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for ADAM19

Target: ADAM19 (Adam19) (ADAM Metallopeptidase Domain 19 (Adam19))

Alternative Name: ADAM19

Background:

Synonyms: Disintegrin and metalloproteinase domain-containing protein 19,ADAM 19,3.4.24.-,Meltrin-beta,Metalloprotease and disintegrin dendritic antigen marker,MADDAM,ADAM19,MLTNB,FKSG34,

Tissue Specificity: Expressed in many normal organ tissues and several cancer cell lines.

Background: ADAM19 (A Disintegrin and Metalloproteinase Domain 19), also known as MLTNB, is a human gene. This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has also been demonstrated to be an active metalloproteinase, which may be involved in normal physiological and pathological processes such as cells migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. Hirohata et al. (1998) used radiation hybrids to map ADAM19 to mouse chromosome 11 and to human chromosome 5q32-q33.

Sequence Similarities: Contains 1 disintegrin domain.

Molecular Weight: 105 kDa

UniProt: Q9H013