CSF3R antibody (Middle Region)

Catalog No. ABIN3044116

This Rabbit Polyclonal antibody specifically detects CSF3R in WB. It exhibits reactivity toward Human.

Quick Overview for CSF3R antibody (Middle Region) (ABIN3044116)

Target: CSF3R (Colony Stimulating Factor 3 Receptor (Granulocyte) (CSF3R))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CSF3R antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CSF3R Antibody

Binding Specificity: Middle Region

Purpose: Anti-GCSF Receptor/CSF3R Antibody

Sequence: EPWQPGLHIN QKCELRHK

Specificity: No cross reactivity with other proteins.

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-GCSF Receptor/CSF3R Antibody. Tested in WB applications. This antibody reacts with Human.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human GCSF Receptor.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Human

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains antibody formulated with stabilizing components, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Preservative: Thimerosal (Merthiolate), Sodium azide

Precaution of Use: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CSF3R

Target: CSF3R (Colony Stimulating Factor 3 Receptor (Granulocyte) (CSF3R))

Alternative Name: CSF3R

Background:

Background: CSF3R (Colony-Stimulating Factor 3 Receptor, Granulocyte) also known as GCSFR or CD114 ( (Cluster of Differentiation 114) is a protein that in humans is encoded by the CSF3R gene. G-CSF-R is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF). The G-CSF receptors belongs to a family of cytokine receptors known as the hematopoietin receptor family. The CSF3R gene consists of 17 exons. By in situ hybridization using human CSF3R cDNA as a probe, Inazawa et al. (1991) localized the gene to 1p35-p34.3. The G-CSF-R is a transmembrane receptor that consists of an extracellular ligand-binding portion, a transmembrane domain, and the cytoplasmic portion that is responsible for signal transduction. GCSF-R ligand-binding is associated with dimerization of the receptor and signal transduction through proteins including Jak, Lyn, STAT, and Erk1/2. Dong et al. (2001) reported that the C terminus of CSF3R is required for SHP1 downregulation of CSF3-induced STAT activation. The authors proposed that this mechanism inhibits cell proliferation and survival in response to CSF3.

Gene Full Name: colony stimulating factor 3 receptor

Sequence Similarities: Belongs to the type I cytokine receptor family. Type 2 subfamily.

Molecular Weight: 108 kDa

Gene ID: 1441

UniProt: Q99062