FGF23 antibody (AA 48-251)

Catalog No. ABIN3044523

This anti-FGF23 antibody is a Rabbit Polyclonal antibody detecting FGF23 in WB. Suitable for Mouse. This Primary Antibody has been cited in 1 publication.

Quick Overview for FGF23 antibody (AA 48-251) (ABIN3044523)

Target: FGF23 (Fibroblast Growth Factor 23 (FGF23))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FGF23 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FGF23 Antibody

Binding Specificity: AA 48-251

Purpose: Anti-FGF23 Antibody Picoband®

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-FGF23 Antibody Picoband® (ABIN3044523). Tested in WB applications. This antibody reacts with Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: E. coli-derived mouse FGF23 recombinant protein (Position: R48-V251). Mouse FGF23 shares 71.1% and 94.6% amino acid (aa) sequence identity with human and rat FGF23, respectively.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Mouse
1. "Entrez Gene: FGF23 fibroblast growth factor 23". 2. Fukumoto S (2008). "Physiological regulation and disorders of phosphate metabolism--pivotal role of fibroblast growth factor 23". Intern. Med. 47 (5): 337-43. 3. Yamashita T, Yoshioka M, Itoh N (October 2000). "Identification of a novel fibroblast growth factor, FGF-23, preferentially expressed in the ventrolateral thalamic nucleus of the brain". Biochem. Biophys. Res. Commun.277 (2): 494-8.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

References for anti-FGF23 antibody (ABIN3044523)

Ji, Ling, Zhang, Chou, Yang, Wang, Yin, Wu, Yu: "MicroRNA-296 mediated corneal neovascularization in an animal model of corneal burns after alkali exposures." in: Experimental and therapeutic medicine, Vol. 15, Issue 1, pp. 139-144, (2018) (PubMed).

Target Details for FGF23

Target: FGF23 (Fibroblast Growth Factor 23 (FGF23))

Alternative Name: Fgf23

Background:

Synonyms: Fibroblast growth factor 23,FGF-23,Fgf23,

Tissue Specificity: Mainly expressed in the brain and thymus at low levels. In brain, preferentially expressed in the ventrolateral thalamic nucleus.

Background: Fibroblast growth factor 23?or?FGF23?is a?protein?that in humans is encoded by the?FGF23?gene. This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC).

Molecular Weight: 34 kDa

Gene ID: 64654

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Negative Regulation of Hormone Secretion