PAK3 antibody (N-Term)

Catalog No. ABIN3044532

This anti-PAK3 antibody is a Rabbit Polyclonal antibody detecting PAK3 in WB. Suitable for Human, Mouse and Rat.

Quick Overview for PAK3 antibody (N-Term) (ABIN3044532)

Target: PAK3

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAK3 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PAK3 Antibody

Binding Specificity: AA 13-49, N-Term

Purpose: Anti-PAK3 Antibody Picoband®

Sequence: APPLRMNSNN RDSSALNHSS KPLPMAPEEK NKKARLR

Cross-Reactivity (Details): No cross-reactivity with other proteins.

Characteristics: Anti-PAK3 Antibody Picoband® (ABIN3044532). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human PAK3, identical to the related mouse and rat sequences.

Isotype: IgG

Application Details

Application Notes: Western blot, 0.1-0.5 μg/mL, Mouse, Rat, Human
1. "Entrez Gene: PAK3 p21 (CDKN1A)-activated kinase 3". 2. Allen KM, Gleeson JG, Bagrodia S, Partington MW, MacMillan JC, Cerione RA, Mulley JC, Walsh CA (Oct 1998). "PAK3 mutation in nonsyndromic X-linked mental retardation". Nat Genet 20 (1): 25-30. 3. Donnelly AJ, Partington MW, Ryan AK, Mulley JC (Nov 1996). "Regional localisation of two non-specific X-linked mental retardation genes (MRX30 and MRX31)". Am J Med Genet 64 (1): 113-20.

Comment:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Target Details for PAK3

Target: PAK3

Alternative Name: PAK3

Background:

Synonyms: Serine/threonine-protein kinase PAK 3,2.7.11.1,Beta-PAK,Oligophrenin-3,p21-activated kinase 3,PAK-3,PAK3,OPHN3,

Tissue Specificity: Restricted to the nervous system. Highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus. .

Background: Serine/threonine-protein kinase PAK 3?is an?enzyme?that in humans is encoded by the?PAK3?gene. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. The protein encoded by this gene forms an activated complex with GTP-bound RAS-like (P21), CDC2 and RAC1 proteins which then catalyzes a variety of targets. This protein may be necessary for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity. Defects in this gene are the cause of non-syndromic mental retardation X-linked type 30 (MRX30), also called X-linked mental retardation type 47 (MRX47). Alternatively spliced transcript variants encoding different isoforms have been identified.

Molecular Weight: 62 kDa

Gene ID: 5063

UniProt: O75914