Epstein-Barr Virus Nuclear Antigen-3A (EBNA-3A) antibody

Catalog No. ABIN306583

This Sheep Polyclonal antibody specifically detects Epstein-Barr Virus Nuclear Antigen-3A in ELISA, IHC (fro), IHC (p), DB, ICC and WB. It exhibits reactivity toward Virus.

Quick Overview for Epstein-Barr Virus Nuclear Antigen-3A (EBNA-3A) antibody (ABIN306583)

Target: Epstein-Barr Virus Nuclear Antigen-3A (EBNA-3A)

Reactivity: Virus

Host: Sheep

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Dot Blot (DB), Immunocytochemistry (ICC), Western Blotting (WB)

Product Details

Purpose: Sheep anti EBNA 3A

Characteristics: EBNA-3A is a latent viral nuclear protein expressed in EBV transformed lymphoblastic cell lines. It is also found in some immunoblastic lymphomas in vivo. This viral nuclear protein is essential for EBV mediated transformation of B lymphocytes. The EBNA-3A functions as a transcriptional regulator though the target genes are currently unknown. Plays an essential role for activation and immortalization of human B-cells. Represses transcription of viral promoters TP1 and Cp through interaction with host RBPJ, and inhibits EBNA2-mediated activation of these promoters. Since Cp is the promoter for all EBNA mRNAs, EBNA3A probably contributes to a negative autoregulatory control loop

Purification: Ammonium Sulfate Precipitation

Isotype: IgG

Application Details

Application Notes: Western blotting at 0.25-1.00 μg/mL, Dot blotting, ELISA, Immunocytochemistry and Immunohistochemistry on frozen and paraffin embedded tissues. Optimal concentrations must be determined by titration.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Details

Target: Epstein-Barr Virus Nuclear Antigen-3A (EBNA-3A)

Alternative Name: EBNA 3A

Target Type: Viral Protein

Background: EBNA3A, Epstein Barr Nuclear Antigen 3A

UniProt: Q69138