p107 antibody

Catalog No. ABIN306628

This Mouse Monoclonal antibody specifically detects p107 in . It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for p107 antibody (ABIN306628)

Target: p107 (RBL1) (Retinoblastoma-Like 1 (p107) (RBL1))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This p107 antibody is un-conjugated

Application: Please inquire

Clone: KAB6

Product Details anti-p107 Antibody

Isotype: IgG1

Application Details

Restrictions: For Research Use only

Handling

Target Details for p107

Target: p107 (RBL1) (Retinoblastoma-Like 1 (p107) (RBL1))

Alternative Name: p107

Background: The immunogen used was a GST fusion protein to the N terminus of p107. p107 is related both in structure and function to the retinoblastoma tumor suppressor protein and p130 (collectively known as pocket proteins) and are known to regulate the activity of E2F transcription factors. E2F transcription factors regulate the expression of a number of genes important in cell proliferation, particularly those involved in the progression through G1 and into the S-phase of the cell cycle. Binding of p107 converts E2F transcription factors from transcriptional activators to transcriptional repressors. KAB6 recognizes both the phosphorylated and unphosphorylated forms of p107 at a MW of 107kDa. Synonyms: p107, Retinoblastoma-like protein 1, PRB1, 107 kda retinoblastoma-associated protein.

UniProt: P28749

Pathways: Cell Division Cycle, Mitotic G1-G1/S Phases