LMO2 antibody (full length)

Catalog No. ABIN306631

This Sheep Polyclonal antibody specifically detects LMO2 in WB. It exhibits reactivity toward Human.

Quick Overview for LMO2 antibody (full length) (ABIN306631)

Target: LMO2 (LIM Domain Only 2 (Rhombotin-Like 1) (LMO2))

Reactivity: Human

Host: Sheep

Clonality: Polyclonal

Conjugate: This LMO2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-LMO2 Antibody

Binding Specificity: full length

Purpose: Sheep anti Human Rhombotin 2

Characteristics: Two homologues of the rhombotin gene have now been isolated. One of these, designated Rhom-2, is located on human chromosome 11 at band 11p13, where a cluster of T-cell leukemia-specific translocations occur, all translocation breakpoints at 11p13 are upstream of the Rhom-2 gene. Human and mouse Rhom-2 are highly conserved and, like rhombotin, encode two tandem cysteine-rich LIM domains. Rhom-2 mRNA is expressed in early mouse development in central nervous system, lung, kidney, liver, and spleen but only very low levels occur in thymus. The Rhom-2 gene is such a common site of chromosomal damage in T-cell tumors. Chromosome bands 11p15 (rhombotin) and 11p13 (Rhom-2) are consistent sites of chromosome translocation in T-cell leukemia, with the 11p15 target more rarely involved.

Purification: Ammonium Sulfate Precipitation

Immunogen: Full length rhombotin 2 protein

Isotype: IgG

Application Details

Application Notes: Western Blots at 1-10 μg /mL

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Details for LMO2

Target: LMO2 (LIM Domain Only 2 (Rhombotin-Like 1) (LMO2))

Alternative Name: Rhombotin 2

Background: LIM domain only protein, cysteine-rich protein TTG-2, T-cell translocation protein 2

UniProt: P25791

Pathways: Chromatin Binding