EPH Receptor B1 antibody (AA 620-1596)

Catalog No. ABIN306670

This Sheep Polyclonal antibody specifically detects EPH Receptor B1 in WB, IHC and IP. It exhibits reactivity toward Human.

Quick Overview for EPH Receptor B1 antibody (AA 620-1596) (ABIN306670)

Target: EPH Receptor B1 (EPHB1)

Reactivity: Human

Host: Sheep

Clonality: Polyclonal

Conjugate: This EPH Receptor B1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Product Details anti-EPH Receptor B1 Antibody

Binding Specificity: AA 620-1596

Cross-Reactivity: Rat

Characteristics: Eph B1 (ELK receptor) SAM, Tyrosine-protein kinase receptor EPH-2, Ephrin type B receptor 1, HEK6,Activation of protein kinase C is a key signal transduction event in mesangial cell dedifferentiation and proliferation, yet little is known about downstream substrates or their roles in normal or diseased states. SSeCKS, a novel protein kinase C substrate originally isolated as a src-suppressed negative mitogenic regulator in fibroblasts, controls actinbased cytoskeletal architecture and scaffolds key signaling kinases such as protein kinase C and protein kinase A. Activation of protein kinase C is a key signal transduction event in mesangial cell dedifferentiation. A role for SSeCKS, a PKA/PKC scaffolding protein, has been implicated during the process of spermiogenesis and in the actin-based stellate morphology of mesangial cells

Purification: Ammonium Sulfate Precipitation

Immunogen: Sheep were immunized with a recombinant protein corresponding to amino acids 620-1596 of the SSeCKS protein.

Isotype: IgG

Application Details

Application Notes: Antibody can be used for Western blot (2-5 μg/mL), immunohistochemistry and immunoprecipitation. Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Handling

Buffer: Provided as solution in phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Details for EPH Receptor B1

Target: EPH Receptor B1 (EPHB1)

Alternative Name: ELK rec tyr Kinase (Eph B1 SAM)

Pathways: RTK Signaling