SMC2 antibody (AA 523-768)

Catalog No. ABIN306862

This Mouse Monoclonal antibody specifically detects SMC2 in WB. It exhibits reactivity toward Human.

Quick Overview for SMC2 antibody (AA 523-768) (ABIN306862)

Target: SMC2 (Structural Maintenance of Chromosomes 2 (SMC2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SMC2 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: E1M

Product Details anti-SMC2 Antibody

Binding Specificity: AA 523-768

Cross-Reactivity: Human

Characteristics: CAP-E, Structural maintenance of chromosomes protein 2, SMC-2,CAP-E and CAP-C (Chromosome Associated Protein-E & C) are also SMC (Structural Maintenance of Chromosome) family members that form a heterodimeric complex required for mitotic chromosome condensation to achieve proper segregation of genetic information during subsequent cell division. hCAP-C/hCAP-E is a component of a multiprotein complex called condensin that interacts with phosphorylation of Histone H3 resulting in the mitotic chromosome condensation. The distribution patterns of the two heterodimeric complexes in interphase nucleus indicate independent behaviour of the two complexes during cell cycle. These results suggest that the two distinct complexes are involved in different aspects of mitotic chromosome organization in human cells.

Purification: Protein A/G Chromatography

Immunogen: Hybridoma produced by the fusion of splenocytes from mice immunized with recombinant protein corresponding to amino acids 523-768 of human CAP-E and mouse myeloma cells.

Isotype: IgG

Application Details

Application Notes: This antibody can be used for Western blotting (1-5 μg/mL). Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Handling

Buffer: Provided as solution in phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Details for SMC2

Target: SMC2 (Structural Maintenance of Chromosomes 2 (SMC2))

Alternative Name: Chromosome Associated Protein-E

UniProt: O95347