CERS6 antibody

Catalog No. ABIN307137

The Rabbit Polyclonal anti-CERS6 antibody (ABIN307137) specifically detects CERS6 in WB. The antibody is reactive with Human samples.

Quick Overview for CERS6 antibody (ABIN307137)

Target: CERS6 (Ceramide Synthase 6 (CERS6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CERS6 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-CERS6 Antibody

Purpose: Rabbit anti Human Lass6

Cross-Reactivity: Human

Characteristics: Longevity assurance genes (LAGs) represent a subgroup of the homeobox gene family. Five mammalian homologs have been reported, and the corresponding proteins have previously been investigated with respect to their key role in ceramide synthesis. However, members of the LAG family have been shown to be involved in cell growth regulation and cancer differentiation. May be involved in sphingolipid synthesis or its regulation. Interacts with ATP6V0C, ASGR1, ASGR2 and SLC22A1/OCT1. Localized to nuclear membrane a multi-pass membrane protein, may be expressed on endoplasmic reticulum membrane. Glycosylation on Asn-18 is not necessary for function. Like other LAG family members, the LASS6 protein contained a homeodomain and LAG1 domain. Lass6 displays highest homology to LASS5. The corresponding gene was localized to human chromosome 2q24.3, spanning a rather large genomic region of 318 kb. Sequences in mouse and zebrafish suggested a conservation of LASS6 in vertebrates because the protein and corresponding genomic sequences are highly conserved. LASS6 was shown to be broadly expressed in a wide range of tissues. Recent data suggested a role in cancer differentiation and early embryonic development.

Purification: Ammonium Sulfate Precipitation

Immunogen: Synthetic peptide dervied from human Lass6 protein

Application Details

Application Notes: Antibody can be used for Western blotting (5-7 μg/mL). Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Details for CERS6

Target: CERS6 (Ceramide Synthase 6 (CERS6))

Alternative Name: Lass6

Background: LAG1 longevity assurance homolog 6

UniProt: Q6ZMG9