ALOX5AP antibody

Catalog No. ABIN307146

The Rabbit Polyclonal anti-ALOX5AP antibody (ABIN307146) specifically detects ALOX5AP in WB. The antibody is reactive with Human samples.

Quick Overview for ALOX5AP antibody (ABIN307146)

Target: ALOX5AP (Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ALOX5AP antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ALOX5AP Antibody

Purpose: Rabbit anti Human FLAP

Cross-Reactivity: Human

Characteristics: Seems to be required for the activation of 5-LO (5-lipoxygenase). Could play an essential role in the transfer of arachidonic acid to 5-LO. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes. Genetic variations in FLAP may be a cause of susceptibility to ischemic stroke [MIM:601367], also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.

Purification: Ammonium Sulfate Precipitation

Immunogen: Synthetic peptide derived from human FLAP protein.

Application Details

Application Notes: Antibody can be used for Western blotting (1-5 μg/mL). Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Details for ALOX5AP

Target: ALOX5AP (Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP))

Alternative Name: FLAP

Background: FLAP, Arachidonate 5-lipoxygenase-activating protein, MK 886 binding protein

UniProt: P20292