GLI1 antibody

Catalog No. ABIN307152

The Rabbit Polyclonal anti-GLI1 antibody (ABIN307152) specifically detects GLI1 in WB. The antibody is reactive with Human samples.

Quick Overview for GLI1 antibody (ABIN307152)

Target: GLI1 (Zinc Finger Protein GLI1 (GLI1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GLI1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-GLI1 Antibody

Purpose: Rabbit anti Human Zinc Finger Protein GLI1

Cross-Reactivity: Human

Characteristics: Zinc Finger Protein GLI1 is a member of the Kruppel family of zinc finger proteins. It is thought that it may regulate the transcription of specific genes during normal development and may play a role in craniofacial development and digital development. It also may be involved in the development of the central nervous system and gastrointestinal tract. This protein mediates SHH signaling and thus cell proliferation and differentiation. It has been localized to the cytoplasm and nucleus. It is tethered in the cytoplasm by binding to SUFU and activation and translocalization to the nucleus is promoted by interation with STK36. Protein expression is amplified in glioblastoma cells. Defects in the GLI1 protein may be a cause of breast cancer.

Purification: Ammonium Sulfate Precipitation

Immunogen: Synthetic peptide derived from human zinc finger protein GLI1.

Application Details

Application Notes: Antibody can be used for Western blotting (1:400 starting dilution). Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Details for GLI1

Target: GLI1 (Zinc Finger Protein GLI1 (GLI1))

Alternative Name: Zinc Finger Protein GLI1

Background: Glioma-associated oncogene, Oncogene GLI

UniProt: P08151

Pathways: Hedgehog Signaling, Dopaminergic Neurogenesis