Glypican 3 antibody (C-Term)

Catalog No. ABIN307157

The Sheep Polyclonal anti-Glypican 3 antibody has been validated for WB and IHC (p). It is suitable to detect Glypican 3 in samples from Human.

Quick Overview for Glypican 3 antibody (C-Term) (ABIN307157)

Target: Glypican 3 (GPC3)

Reactivity: Human

Host: Sheep

Clonality: Polyclonal

Conjugate: This Glypican 3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-Glypican 3 Antibody

Binding Specificity: C-Term

Cross-Reactivity: Human

Characteristics: GPC3, GPC-3, OCI5, OCI-5, GTR2-2, MXR7,Glypican-3 encodes a putative extracellular proteoglycan that is inferred to play an important role in growth control in embryonic mesodermal tissues in which it is selectively expressed. It appears to form a complex with insulin-like growth factor and hence modulate IGF2 action. Glypican-3 is the human homolog of OCI-5, a GPI-linked proteoglycan first isolated from rat intestine. Originally identified as the molecular basis for Simpson-Golabi-Behmel syndrome (SGBS) also called Simpson dysmorphia syndrome (SDYS).

Purification: Total IgG

Immunogen: C terminal recombinant protein (~70aa) which does not overlap with clone 1G12 epitope)

Isotype: IgG

Application Details

Application Notes: Antibody can be used for immunohistochemistry on paraffin-embedded tissues (10 μg/mL) and Western blotting (5-10 μg/mL). Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Handling

Buffer: Provided as solution in phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Details for Glypican 3

Target: Glypican 3 (GPC3)

Alternative Name: Glypican-3 (GPC3)

UniProt: P51654

Pathways: Glycosaminoglycan Metabolic Process