Tyrosine Hydroxylase antibody

Catalog No. ABIN308677

This Sheep Polyclonal antibody specifically detects Tyrosine Hydroxylase in WB, IHC, IF and ICC. It exhibits reactivity toward Human, Rat, Mouse and Protozoa.

Quick Overview for Tyrosine Hydroxylase antibody (ABIN308677)

Target: Tyrosine Hydroxylase (TH)

Reactivity: Human, Rat, Mouse, Protozoa

Host: Sheep

Clonality: Polyclonal

Conjugate: This Tyrosine Hydroxylase antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Product Details anti-Tyrosine Hydroxylase Antibody

Cross-Reactivity: Human, Mouse (Murine), Primate, Rat (Rattus)

Purification: affinity purified

Immunogen: Native rat tyrosine hydroxylase purified from pheochromocytoma.

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Storage: -20 °C

Target Details for Tyrosine Hydroxylase

Target: Tyrosine Hydroxylase (TH)

Alternative Name: Tyrosine Hydroxylase

Background: Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines dopamine, epinephrine and norepinephrine. Therefore the regulation of the TH enzyme represents the central means for controlling the synthesis of these important catecholamines. TH has a large molecular diversity, resulting from differential splicing of its mRNA, which is tissue specific and might result in long term changes in activity of the enzyme and the availability of neurotransmitter at various synapses. The presence of different DNA sequences at the TH locus confers susceptibility to various disorders of the brain including manic-depression and schizophrenia. Parkinson's disease is also considered a TH deficiency, as low dopamine levels are a consistent neurochemical abnormality.

Pathways: Dopaminergic Neurogenesis, Response to Water Deprivation, Sensory Perception of Sound, Carbohydrate Homeostasis, Feeding Behaviour