SIGLEC7 antibody

Catalog No. ABIN316977

This anti-SIGLEC7 antibody is a Mouse Monoclonal antibody detecting SIGLEC7 in FACS and IHC (fro). Suitable for Human.

Quick Overview for SIGLEC7 antibody (ABIN316977)

Target: SIGLEC7 (Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This SIGLEC7 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: 30-04-86

Product Details anti-SIGLEC7 Antibody

Specificity: This antibody is specific for CDw328.

Characteristics: Synonyms: Siglec-7, QA79 membrane protein, p75, D-siglec, CDw328, AIRM1, Sialic acid-binding Ig-likelectin 7, Adhesion inhibitory receptor molecule 1

Purification: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Immunogen: Monocyte-derived dendritic cells

Isotype: IgG1

Application Details

Application Notes: Flow Cytometry: 1/100 - 1/200. Immunohistochemistry on frozen sections: 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0mg/mL

Buffer: Phosphate buffered saline pH 7.4 containing 0.09 % Sodium Azide (NaN3)

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch. Caution: (A full Health and Safety assessment is available upon request) This product containsSodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled bytrained staff only.

Expiry Date: 12 months

Target Details for SIGLEC7

Target: SIGLEC7 (Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7))

Alternative Name: CD328 / SIGLEC7

Background: CDw328 is a type I transmembrane glycoprotein and member of the Siglec (sialic acid binding Ig-like lectin) family, designated Siglec-7, originally identified as an inhibitory NK cell receptor (NKR) and negative regulator of NK activation, attributed to ITIM recruitment of SHP-1 phosphatase. CDw328 is expressed predominantly by natural killer cells (NK) and to a lesser extent by monocytes and granulocytes and, like Siglec-5 (CD170), has been shown to bind to sialylated ligands of targets through recognition of sialic acid in both the alpha-2,3- and alpha-2,6- glycosidic linkage.Synonyms: AIRM1, Adhesion inhibitory receptor molecule 1, CDw328, D-siglec, QA79 membrane protein, Sialic acid-binding Ig-like lectin 7, Siglec-7, p75

Gene ID: 27036

UniProt: Q9Y286