NPPB antibody (N-Term)

Catalog No. ABIN317050

This Mouse Monoclonal antibody specifically detects NPPB in WB and EIA. It exhibits reactivity toward Human.

Quick Overview for NPPB antibody (N-Term) (ABIN317050)

Target: NPPB (Natriuretic Peptides B (NPPB))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This NPPB antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Clone: 5-00E-002

Product Details anti-NPPB Antibody

Binding Specificity: AA 1-32, N-Term

Specificity: This antibody detects an epitope located at the C-terminal (amino acids 26-32) of the brain natriuretic peptide (BNP), a secreted protein which is a member of the natriuretic peptide family. This antibody also detects proBNP.

Characteristics: Synonyms: NPPB

Purification: Purified IgG prepared by affinity chromatography on Protein A

Immunogen: Human synthetic BNP.

Isotype: IgG1

Application Details

Application Notes: ELISA. Western Blot: detects a band of approximately 4 kDa when using synthetic BNP and a bandof 14 kDa when using recombinant proBNP. Immunoassay.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0mg/mL

Buffer: Phosphate buffered saline pH 7.4 containing 0.09 % Sodium Azide (NaN3)

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch. Caution: (A full Health and Safety assessment is available upon request) This product containsSodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by

Expiry Date: 12 months

Target Details for NPPB

Target: NPPB (Natriuretic Peptides B (NPPB))

Alternative Name: Natriuretic Peptides B

Background: BNP is a cardiac hormone, which is synthesised as a pro-hormone (proBNP), and is proteolytically cleaved to release a biologically active fragment (BNP), and an inactive fragment (NT-proBNP) into the circulation. BNP is predominantly secreted from the cardiac ventricles in response to volume and pressure overload, and results in a number of biological activities including natriuresis, diuresis, vasorelaxation, and inhibition of the sympathetic nervous system. A high concentration of BNP in the bloodstream is indicative of heart failure.Synonyms: NPPB

Gene ID: 4879

UniProt: P16860

Pathways: Hormone Activity