Annexin V antibody

Catalog No. ABIN317104

This Mouse Monoclonal antibody specifically detects Annexin V in FACS and EIA. It exhibits reactivity toward Human.

Quick Overview for Annexin V antibody (ABIN317104)

Target: Annexin V (ANXA5) (Annexin A5 (ANXA5))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Annexin V antibody is un-conjugated

Application: Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Clone: VAA-33

Product Details anti-Annexin V Antibody

Specificity: This antibody specifically recognizes Annexin V. Clone VAA-33 has been reported to work in western blotting applications.

Characteristics: Synonyms: Annexin-5, Annexin V, Lipocortin V, Endonexin II, Calphobindin I, Anchorin CII, ANX5, ENX2,PP4, CBP-I, PAP-I, VAC-alpha, Placental anticoagulant protein I, Placental anticoagulantprotein 4, Thromboplastin inhibitor, Vascular anticoagulant-alpha

Purification: Purified IgG prepared by affinity chromatography on Protein G

Immunogen: Recombinant Annexin V

Isotype: IgG2a

Application Details

Application Notes: Flow Cytometry. ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0mg/mL

Buffer: PBS, 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for Annexin V

Target: Annexin V (ANXA5) (Annexin A5 (ANXA5))

Alternative Name: Annexin A5 / ANXA5

Background: AnnexinV is a phospholipid binding protein which binds with high affinity and selectivity to phosphatidylserine (PS), in the presence of calcium. The translocation of PS from the cytosolic leaflet to the outer leaflet of the plasma membrane, due to a loss in plasma membrane asymmetry during apoptosis, acts as an in vivo signal for the removal of the dying cell by phagocytosis. Detection of PS using Annexin V therefore provides a reliable diagnostic tool for the indication of early programmed cell death. Annexin V has also been identified as an anticoagulant protein in the blood coagulation cascade, by acting as an inhibitor of prothrombin activation. The presence of antibodies to Annexin V, are associated with systemic lupus erythematosus (SLE), recurrent spontaneous abortions and systemic sclerosis (SSc).Synonyms: ANX5, Anchorin CII, Annexin V, Annexin-5, CBP-I, Calphobindin I, ENX2, Endonexin II, Lipocortin V, PAP-I, PP4, Placental anticoagulant protein 4, Placental anticoagulant protein I, Thromboplastin inhibitor, VAC-alpha, Vascular anticoagulant-alpha

Gene ID: 308

UniProt: P08758

Pathways: Apoptosis