AKAP13 antibody

Catalog No. ABIN317612

The Rabbit Polyclonal anti-AKAP13 antibody is suitable to detect AKAP13 in samples from Human. It has been validated for WB and IHC (p).

Quick Overview for AKAP13 antibody (ABIN317612)

Target: AKAP13 (A Kinase (PRKA) Anchor Protein 13 (AKAP13))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AKAP13 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-AKAP13 Antibody

Specificity: This antibody detects endogenous levels of AKAP13 Protein.(region surrounding Asp738)

Purification: Affinity Chromatography using epitope-specific immunogen.

Application Details

Application Notes: Western Blot: 1/500-1/1000. ELISA: 1/20000-1/40000. Immunohistochemistry: 1/50-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2 containing 0,05 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for AKAP13

Target: AKAP13 (A Kinase (PRKA) Anchor Protein 13 (AKAP13))

Alternative Name: AKAP13

Background: AKAP13 functions as a protein kinase A (PKA)-anchoring protein and acts as an adapter protein to selectively couple G alpha-13 and Rho. It contains a dbl oncogene homology (DH) domain and a pleckstrin homology (PH) domain. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins. AKAP13 augments gene activation by the estrogen receptor and activates estrogen receptor beta by a p38 MAPK-dependent pathway. AKAP13 is involved in the signaling pathways leading to cardiomyocytes hypertrophy.Synonyms: A-kinase anchor protein 13, AKAP-Lbc, BRX, Breast cancer nuclear receptor-binding auxiliary protein, Guanine nucleotide exchange factor Lbc, HT31, Human thyroid-anchoring protein 31, LBC, Lymphoid blast crisis oncogene, Non-oncogenic Rho GTPase-specific GTP exchange factor, P47, Protein kinase A-anchoring protein 13

Gene ID: 11214

NCBI Accession: NP_006729

UniProt: Q12802

Pathways: Neurotrophin Signaling Pathway