beta 2 Adrenergic Receptor antibody

Catalog No. ABIN317627

The Rabbit Polyclonal anti-beta 2 Adrenergic Receptor antibody is suitable to detect beta 2 Adrenergic Receptor in samples from Human. It has been validated for WB, IF and IHC (p).

Quick Overview for beta 2 Adrenergic Receptor antibody (ABIN317627)

Target: beta 2 Adrenergic Receptor (ADRB2) (Adrenergic, beta-2-, Receptor, Surface (ADRB2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This beta 2 Adrenergic Receptor antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-beta 2 Adrenergic Receptor Antibody

Specificity: This antibody detects endogenous levels of AR-beta2 protein.(region surrounding Cys378)

Purification: Affinity Chromatography using epitope-specific immunogen.

Application Details

Application Notes: ELISA: 1/5000-1/20000. Western Blot: 1/500-1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2 containing 0,05 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for beta 2 Adrenergic Receptor

Target: beta 2 Adrenergic Receptor (ADRB2) (Adrenergic, beta-2-, Receptor, Surface (ADRB2))

Alternative Name: beta-2 Adrenergic Receptor

Background: Adrenergic receptors (ARs) (the term ?adrenergic? reflects the alternative name for epinephrine, adrenaline) include four general types (alpha1, alpha2, beta1 and beta2) which are found in different target tissues and differ in their affinities and responses to various agonists and antagonists. cDNA clones have been isolated for all of the major AR subtypes and a number of closely related receptors have been identified by this approach. Each of the receptors have been shown to consist of single polypeptide chains which transverse the plasma membrane seven times, presumably forming a bundle of helices within the membrane. These transmembrane regions are hydrophobic and are interconnected by extracellular and intracellular hydrophilic loops. The coupling of ARs to specific intracellular effectors is mediated through diverse heterotrimeric G proteins and is regulated by G protein-coupled receptor kinases (GRKs), cAMP-dependent protein kinase A and protein kinase C directed phosphorylation.Synonyms: ADRB2, ADRB2R, B2AR, Beta-2 adrenoreceptor

Gene ID: 9606

UniProt: P07550

Pathways: cAMP Metabolic Process, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Brown Fat Cell Differentiation