G Protein-Coupled Receptor 119 antibody

Catalog No. ABIN317642

The Rabbit Polyclonal anti-G Protein-Coupled Receptor 119 antibody is suitable to detect G Protein-Coupled Receptor 119 in samples from Human. It has been validated for WB and IF.

Quick Overview for G Protein-Coupled Receptor 119 antibody (ABIN317642)

Target: G Protein-Coupled Receptor 119 (GPR119)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This G Protein-Coupled Receptor 119 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-G Protein-Coupled Receptor 119 Antibody

Specificity: This antibody detects endogenous levels of GPR119 protein.(region surrounding Val227)

Purification: Affinity Chromatography using epitope-specific immunogen.

Application Details

Application Notes: ELISA: 1/1000-1/5000. Western Blot: 1/500-1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2 containing 0,05 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for G Protein-Coupled Receptor 119

Target: G Protein-Coupled Receptor 119 (GPR119)

Alternative Name: GPR119

Background: G protein-coupled receptors (GPRs) are a protein family of transmembrane receptors that transmit an extracellular signal (ligand binding) into an intra cellular signal (G protein activation). GPR signaling is an evolutionarily ancient mechanism used by all eukaryotes to sense environmental stimuli and mediate cell-cell communication. All of the receptors have seven membrane- spanning domains and the extracellular parts of the receptor can be glycosylated. These extracellular loops also contain two highly conserved cysteine residues which create disulfide bonds to stabilize the receptor structure. GPR119 is a 335 amino acid protein that is mainly expressed in the pancreas. It is an endogenous receptor for lysophosphatidylcholine (LPC), which is is a lipid mediator involved in insulin secretion from pancreatic cells. GPR119 may participate in this insulin secretion, suggesting that it may be potential target for new anti-diabetic drugs.Synonyms: G-protein coupled receptor 119, Glucose-dependent insulinotropic receptor

Molecular Weight: approx. 37 kDa

Gene ID: 139760

NCBI Accession: NP_848566

UniProt: Q8TDV5

Pathways: Hormone Transport, Peptide Hormone Metabolism