MCHR2 antibody

Catalog No. ABIN317652

Product Details anti-MCHR2 Antibody

Target: MCHR2 (Melanin-Concentrating Hormone Receptor 2 (MCHR2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MCHR2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Specificity: This antibody detects endogenous levels of MCH-2R protein.(region surrounding Met332)

Purification: Affinity Chromatography using epitope-specific immunogen.

Application Details

Application Notes: ELISA: 1/1000-1/5000. Western Blot: 1/500-1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2 containing 0,05 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for MCHR2

Target: MCHR2 (Melanin-Concentrating Hormone Receptor 2 (MCHR2))

Alternative Name: MCHR2 / GPR145 (MCHR2 Products)

Synonyms: GPR145 antibody, GPRv17 antibody, MCH-2R antibody, MCH-R2 antibody, MCH2 antibody, MCH2R antibody, MCHR-2 antibody, SLT antibody, melanin concentrating hormone receptor 2 antibody, MCHR2 antibody

Background: Melanin-concentrating hormone (MCH) is a 19 amino acid cyclic neuropeptide,which is mainly expressed in the hypothalamus. MCH modulates feeding behavior, aggression, anxiety, arousal and reproductive function in mammals by controlling the release of luteinizing hormone (LH). The melanin-concentrating hormone receptor (MCHR, also designated SLC-1) is a glycosylated G-protein coupled receptor that migrates between 45-50 kDa on SDS-PAGE. MCHR mediates the effects of MCH through Gai and/or Gaq signaling and is expressed in several regions of the brain, including the cerebral cortex, amygdala, thalamus and hypothalamus. MCH and MCHR have also been implicated in stimulating leptin expression and secretion in adipocytes, which suggests that the melanin-concentrating hormone and its receptor may be potential targets for modulating obesity.Synonyms: G-protein coupled receptor 145, GPRv17, MCH receptor 2, MCH-2R, MCH-R2, MCHR-2, Melanin-concentrating hormone receptor 2, SLT

Molecular Weight: approx. 39 kDa

Gene ID: 84539

NCBI Accession: NP_001035269

UniProt: Q969V1