HNRNPM antibody

Catalog No. ABIN317716

Product Details anti-HNRNPM Antibody

Target: HNRNPM (Heterogeneous Nuclear Ribonucleoprotein M (HNRNPM))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HNRNPM antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: This antibody detects endogenous levels of hnRNP- M / HNRNPM (region surrounding Pro43).

Cross-Reactivity (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity-chromatography

Application Details

Application Notes: ELISA: 1: 40000approx. 1: 60000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2, 0.05 % Sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for HNRNPM

Target: HNRNPM (Heterogeneous Nuclear Ribonucleoprotein M (HNRNPM))

Alternative Name: HnRNP-M / HNRNPM (HNRNPM Products)

Synonyms: HNRPM antibody, si:ch211-197g15.1 antibody, wu:fa10g07 antibody, wu:fa98b02 antibody, hnrpm antibody, CG9373 antibody, Dmel\\CG9373 antibody, Hrp59 antibody, cg9373 antibody, hnRNP M antibody, hrp59 antibody, p75 antibody, CEAR antibody, HNRNPM4 antibody, HNRPM4 antibody, HTGR1 antibody, NAGR1 antibody, 2610023M21Rik antibody, AA409009 antibody, Hnrpm antibody, mKIAA4193 antibody, Hnrpm4 antibody, heterogeneous nuclear ribonucleoprotein M antibody, Heterogeneous nuclear ribonucleoprotein M antibody, rumpelstiltskin antibody, HNRNPM antibody, hnrnpm antibody, hnrpm antibody, rump antibody, Hnrnpm antibody

Background: Proteins that directly bind to nascent RNA polymerase II transcripts, the heterogenous nuclear ribonucleoproteins (hnRNPs), play an important role in both transcript-specific packaging and alternative splicing of pre-mRNAs. A group of abundant hnRNPs, the M1-M4 proteins, appear as a cluster of four proteins. The M proteins are pre-mRNA binding proteins in vivo, and they bind avidly to poly (G) and poly (U) RNA homopolymers in vitro. M proteins are members of the ribonucleoprotein consensus sequence family of RNA-binding proteins with greatest similarity to a hypothetical RNA-binding protein from Saccharomyces cerevisiae. The M proteins also possess an unusual hexapeptide-repeat region rich in methionine and arginine residues (MR repeat motif) that resembles a repeat in the 64 kDa subunit of cleavage stimulation factor, which is involved in 3'-end maturation of pre-mRNAs. Proteins immunologically related to M exist in divergent eukaryotes ranging from human to yeast.Synonyms: HNRPM, Heterogeneous nuclear ribonucleoprotein M, NAGR1

Molecular Weight: approx. 85 kDa

Gene ID: 4670

NCBI Accession: NP_005959

UniProt: P52272