AVPR1B antibody

Catalog No. ABIN317776

This Rabbit Polyclonal antibody specifically detects AVPR1B in WB. It exhibits reactivity toward Human.

Quick Overview for AVPR1B antibody (ABIN317776)

Target: AVPR1B (Arginine Vasopressin Receptor 1B (AVPR1B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AVPR1B antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-AVPR1B Antibody

Specificity: AVP Receptor V3 antibody detects endogenous levels of AVP Receptor V3 protein.

Purification: Affinity chromatography

Application Details

Application Notes: ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for AVPR1B

Target: AVPR1B (Arginine Vasopressin Receptor 1B (AVPR1B))

Alternative Name: Vasopressin V1b Receptor (V1bR)

Background: Vasopressin (AVP), the antidiuretic hormone, is a cyclic nonpeptide that is involved in the regulation of body fluid osmolality. AVP mediates its effects through a family of G protein coupled receptors, the vasopressin receptors type V1a, V2 and V3 (also designated V1b). The AVP receptor V1a is responsible for several functions, including blood vessel constriction, liver glycogenolysis and platelet adhesion. It is detected as an 85-90 kDa full length protein and a 46 kDa protein, which results from proteolytic cleavage of its amino terminus. The V1a receptor is coupled to Gq/11 protein, which increases the intracellular calcium concentration. The human AVP receptor V2 gene maps to chromosome Xq28 and is expressed in lung and kidney. Mutations in the V2 receptor result in nephrogenic diabetes insipidus (NDI), a rare X-linked disorder characterized by the inability of the kidney to concentrate urine in response to AVP. The AVP Receptor V2 activates the Gs protein and the cyclic AMP second messenger system. The AVP receptor V3 is preferentially expressed in the pituitary and stimulates the release of adrenocorticotropic hormone (ACTH) in response to AVP by mobilizing intracellular calcium stores. AVP receptor antagonists may have potential therapeutic effects in hypertension, congestive heart failure, nephrotic syndrome and ACTH-secreting tumors.Synonyms: AVPR V1b, AVPR V3, Antidiuretic hormone receptor 1b, Avpr1b, Vasopressin V3 receptor

Molecular Weight: approx. 47 kDa

Gene ID: 553

NCBI Accession: NP_000698

UniProt: P47901

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones