GNaZ antibody

Catalog No. ABIN317793

Product Details anti-GNaZ Antibody

Target: GNaZ (Guanine Nucleotide Binding Protein (G Protein), alpha Z Polypeptide (GNaZ))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GNaZ antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: Gz-α antibody detects endogenous levels of Gz-α protein.(region surrounding Ala12)

Purification: Affinity chromatography

Application Details

Application Notes: ELISA: 1: 5000approx. 1: 10000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for GNaZ

Target: GNaZ (Guanine Nucleotide Binding Protein (G Protein), alpha Z Polypeptide (GNaZ))

Alternative Name: G Protein Z alpha (GNaZ Products)

Synonyms: GXA antibody, AI847979 antibody, Gz antibody, G protein subunit alpha z antibody, guanine nucleotide binding protein, alpha z subunit antibody, GNAZ antibody, Gnaz antibody

Background: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units, alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. G protein z alpha, encoded by the GNAZ gene, is enriched in neural tissue and differs in sequence from other G alpha subunits. Alpha Subunits are encoded in 15 genes and several transcripts are alternatively spliced. Receptors may discriminate between splice variants, whether splice variants are functionally different in regulating effectors is not known. All alpha subunits appear to be palmitoylated near the N-terminus.Synonyms: G(x) alpha chain, GNAZ, Guanine nucleotide-binding protein G(z) subunit alpha, Gz-alpha

Molecular Weight: approx. 41 kDa

Gene ID: 2781

NCBI Accession: NP_002064

UniProt: P19086

Pathways: G-protein mediated Events