RNF144A
Reactivity: Human
WB, ELISA, IHC
Host: Rabbit
Polyclonal
unconjugated
Application Notes
ELISA: 1: 40000approx. 1: 60000. WB: 1: 500approx. 1: 1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
RNF144 antibody, UBCE7IP4 antibody, AI316797 antibody, Rnf144 antibody, UIP4 antibody, Ubce7ip4 antibody, RGD1561737 antibody, rnf144 antibody, rnf144a antibody, si:dkeyp-7f8.1-001 antibody, wu:fj49a04 antibody, zgc:92582 antibody, ring finger protein 144A antibody, ring finger protein 144ab antibody, RNF144A antibody, Rnf144a antibody, rnf144ab antibody
Background
Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction.The three classes of enzymes involved in ubiquitination are the ubiquitinactivating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). UBCE7IP4 (Ubiquitin-conjugating enzyme 7- interacting protein 4), also known as RNF144A (RING finger protein 144A), KIAA0161 or RNF144, is a 292 amino acid single-pass membrane protein that contains one RING-type zinc finger and two IBR-type zinc fingers. Functioning as an E3 ubiquitin-protein ligase, UBCE7IP4 accepts ubiquitin (in the form of a thioester) from E2 ubiquitin-conjugating enzymes, such as UBC8 and UBCH7, and transfers that ubiquitin residue to target substrates. Via its RING finger, UBCE7IP4 may play a role in protein-DNA and protein-protein interactions throughout the cell.Synonyms: KIAA0161, Probable E3 ubiquitin-protein ligase RNF144A, RING finger protein 144A, RNF144, UbcM4-interacting protein 4, Ubiquitin-conjugating enzyme 7-interacting protein 4, Uip4