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GRB14 antibody

GRB14 Reactivity: Human, Mouse, Rat WB, IHC (p) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN317840
  • Target See all GRB14 Antibodies
    GRB14 (Growth Factor Receptor-Bound Protein 14 (GRB14))
    Reactivity
    • 31
    • 8
    • 7
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 31
    Rabbit
    Clonality
    • 31
    Polyclonal
    Conjugate
    • 13
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GRB14 antibody is un-conjugated
    Application
    • 13
    • 13
    • 12
    • 11
    • 6
    • 4
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Specificity
    GRB14 antibody detects endogenous levels of GRB14 protein.(region surrounding Asp123)
    Purification
    Affinity chromatography
    Top Product
    Discover our top product GRB14 Primary Antibody
  • Application Notes
    ELISA: 1: 40000approx. 1: 60000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1,0 mg/mL
    Buffer
    Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    GRB14 (Growth Factor Receptor-Bound Protein 14 (GRB14))
    Alternative Name
    GRB14 (GRB14 Products)
    Synonyms
    GRB14 antibody, AI505286 antibody, growth factor receptor bound protein 14 antibody, GRB14 antibody, grb14 antibody, Grb14 antibody
    Background
    Many growth factors function by binding receptors with intrinsic tyrosine kinase activity. Signaling by such receptors involves a series of intermediates characterized by SH2 domains that bind tyrosine phosphorylated receptors by a direct interaction between the SH2 domain and specific phosphotyrosine-containing receptor sequences. GRB7, a SH2 domain protein, has a single SH2 domain at its C-terminal, a central region with similarity to Ras GAP and a proline-rich N terminus. A related SH2 domain-containing protein, GRB10, exhibits a high degree of homology with GRB7. GRB10 undergoes serine but not tyrosine phosphorylation in response to EGF treatment, but appears to bind to the EGF receptor poorly. An additional member of the GRB7 family, designated GRB14, contains a pleckstrin homology domain in its central region and a carboxy terminal SH2 domain.Synonyms: GRB14 adapter protein, Growth factor receptor-bound protein 14
    Molecular Weight
    approx. 61 kDa
    Gene ID
    2888
    NCBI Accession
    NP_004481
    UniProt
    Q14449
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