ABCC10 antibody

Catalog No. ABIN317845

Product Details anti-ABCC10 Antibody

Target: ABCC10 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 10 (ABCC10))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ABCC10 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: MRP7 antibody detects endogenous levels of MRP7 protein.(region surrounding Glu865)

Purification: Affinity chromatography

Application Details

Application Notes: ELISA: 1: 40000approx. 1: 60000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for ABCC10

Target: ABCC10 (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 10 (ABCC10))

Alternative Name: ABCC10 / MRP7 (ABCC10 Products)

Synonyms: EST182763 antibody, MRP7 antibody, SIMRP7 antibody, Mrp7 antibody, mFLJ00002 antibody, ATP binding cassette subfamily C member 10 antibody, ATP-binding cassette, sub-family C (CFTR/MRP), member 10 antibody, ABCC10 antibody, Abcc10 antibody

Background: The MRP family is represented by nine similar ABC transporters that have the ability to transport structurally diverse lipophilic anions and operate as chemical efflux pumps. MRP7 (multidrug resistance-associated protein 7, ATPbinding cassette sub-family C member 10) is a multi-pass membrane protein that belongs to the ABC transporter family (conjugate transporter subfamily). MRP7 is involved with the ATP-dependent transport of 17β-estradiol-D-17-β-glucuronide (E217βG). MRP7 is also probably involved in cellular detoxification through its lipophilic anion extrusion capabilities. MRP7 contains two ABC transmembrane type 1 domains and two ABC transporter domains. MRP7 likely has three isoforms. Isoform 2 is the most widely expressed, while isoform 1 is predominately expressed in the spleen.Synonyms: ATP-binding cassette, Multidrug resistance-associated protein 7, SIMRP7, member 10, sub-family C

Molecular Weight: approx. 162 kDa

Gene ID: 89845

NCBI Accession: NP_001185863

UniProt: Q5T3U5